The primary objective of this soar is to demonstrate how Multaq (dronedarone) may aid in the regression or slowing of progression of left atrial and ventricular fibrosis in patients with atrial fibrillation as assessed by LGE-MRI, using longitudinal data from a double-blinded, randomized prospective study of patients diagnosed with atrial fibrillation over a twelve month follow up period.
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RADAR: Effect of Structural Remodeling on Scar Formation as Assessed by DE-MRI of the Left Atrium Following Open Irrigation Cooled-tip Radiofrequency Catheter Ablation of Atrial Fibrillation.
The primary objective of RADAR is to evaluate the impact of pre-ablation structural remodeling (fibrosis) on scar formation and progression in the LA as assessed by DE-MRI in patients who have undergone successful open irrigated cooled-tipped RF ablation of paroxysmal atrial fibrillation (PAF), using observational, longitudinal, retrospective data over a 12 month follow up period.
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CASTLE-AF: Catheter Ablation Versus Standard Conventional Treatment in Patients with Left Ventricular Dysfunction and Atrial Fibrillation.
Objectives: CASTLE-AF is a prospective, randomized, pilot study having as objective the evaluation of the effectiveness of radio frequency catheter-based atrial fibrillation (AF) ablation on mortality and morbidity compared to conventional treatment in subjects suffering from heart failure. About 40 patients with left ventricular dysfunction (ejection fraction ≤ 35%) and New York Heart Association class ≥ II, scheduled implantation of a dual chamber ICD or CRT-D with Home Monitoring capabilities, will be enrolled and randomized 1:1 to undergo either AF ablation or standard treatment as indicated in the ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation. In addition to planned and unplanned visits, the ablated patients will be constantly remotely monitored via Home Monitoring, in order to detect any recurrences of atrial fibrillation episodes, even if non symptomatic or short in duration, during an observational period of a minimum of 3 years per patient.
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Objectives: This study seeks to expand the University of Utah experience with Delayed-Enhancement Magnetic Resonance Imaging (DE-MRI) image acquisition and processing in the management of atrial fibrillation (AF). The specific aims are as follows:
Aim 1: Successfully acquire DE-MRI scans of the left atrium in AF patients and quantify the extent of structural remodeling or fibrosis.
Aim 2: Successfully acquire DE-MRI scans of the left atrium 3 months post catheter ablation, quantify the extent of ablation related scarring and describe its distribution
Aim 3: Evaluate the relative contribution of clinical patient characteristics, pre-ablation fibrosis as well as post-ablation scarring in determining the long-term success of catheter ablation in maintaining normal rhythm.
Status: Open for enrollment
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