Through this study, we would like to identify the inheritance pattern of the MRI-phenotype 'left atrial wall fibrosis'. We would further do a linkage analysis to identify the location of the genes responsible for the LA fibrosis trait. Linkage analysis will be followed with other genetic marker identification methods such as candidate gene sequencing, association analysis and Genome-wide association studies (GWAS) to identify the genes/Single nucleotide polymorphism (SNP) markers that confer a predisposition to LA fibrosis and Atrial fibrillation.
This research protocol will solely be used to create the gene panel based on the results of SNP and GWAS. We will design a study in the future to test the gene panel, at which point a new protocol will be submitted to IRB. Currently, we do not intend to recruit any participants for testing the gene panel within the scope of this protocol.
LAFGH (Left Atrial Fibrosis and Genetic Heritability):
This study is being conducted to characterize left atrial fibrosis in normal population as well as in patients with atrial fibrillation. This data will be used to determine whether there is an identifiable MRI phenotype that predicts the development of atrial fibrillation. The main objectives of the study are
1. To characterize LA fibrosis in a healthy (non-atrial fibrillation) control population.
2. To determine association of left atrial fibrosis with atrial fibrillation.
3. To determine pattern of inheritance of LA fibrosis.
4. To identify genes associated with left atrial fibrosis and atrial fibrillation.