Academics & Research

Nora Eccles Harrison Cardiovascular Research & Training Institute

Publications

2017

Warren M, Sciuto KJ, Taylor TG, Garg V, Torres NS, Shibayama J, Spitzer KW, Zaitsev AV, Blockade of CaMKII Depresses Conduction Preferentially in the Right Ventricular Outflow Tract and Promotes Ischemic Ventricular Fibrillation in the Rabbit Heart. Am J Physiol Heart Circ Physiol 2017 Jan 27;:ajpheart.00347.2016

Giese M.H., A. Gardner, A. Hansen and M.C. Sanguinetti (2017) Molecular mechanisms of Slo2 K+ channel closure. Journal of Physiology 595(7):2321-2336.

Grandi, E., M.C. Sanguinetti, D.C. Bartos, D.M. Bers, Y. Chen-Izu, N. Chiamvimonvat, H.M.  Colecraft, B.P. Delisle, J. Heijman, M.F. Navedo, S. Noskov, C. Proenza, J.I. Vandenberg, V. Yarov Yarovoy. (2017) Potassium channels in the heart: Structure, function and regulation. Journal of Physiology 595(7):2209-2228.

Chiamvimonvat, N., Y. Chen-Izu, C.E. Clancy, I. Deschenes, D. Dobrev, J. Heijman, L.T. Izu, Z. Qu, C.M. Ripplinger, J.I. Vandenberg, J.N. Weiss, G. Koren, T. Banyasz, E. Grandi, M.C. Sanguinetti, D.M. Bers, and J.M. Nerbonne (2017) Potassium channels in the heart: Functional roles in repolarization, arrhythmia, and therapeutics. Journal of Physiology 595(7):2229-2252.

A. Mondal, D. A. Appadurai, N. W. Akoum, F. B. Sachse, and A. P. Moreno. Computational simulations of asymmetric fluxes of large molecules through gap junction channel pores. J Theor Biol, 412:61--73, 2017.

R. B. Clark, T. Schmidt, F. B. Sachse, D. Boyle, G. Firestein, and W. R. Giles. Cellular electrophysiological principles that modulate secretion from synovial fibroblasts. J Physiol, 595(3):635--45, 2017.

T. Seidel, S. Navankasattusas, A. Ahmad, N. A. Diakos, W. D. Xu, M. Tristani-Firouzi, M. J. Bonios, I. Taleb, D. Y. Li, C. H. Selzman, S. G. Drakos, and F. B. Sachse. Sheet-like remodeling of the transverse tubular system in human heart failure impairs excitation-contraction coupling and functional recovery by mechanical unloading. Circ, 2017 Jan 10 (EPub).

2016

Chaudhuri D, Artiga DJ, Abiria SA, Clapham DE. Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition. Proc Natl Acad Sci USA. 2016 Mar 29;113(13):E1872-80

Moreno-Galindo EG, Alamilla J, Sanchez-Chapula JA, Tristani-Firouzi M, Navarro-Polanco RA . The agonist-specific voltage dependence of M2 muscarinic receptors modulates the deactivation of the acetylcholine-gated K(+) current (I KACh) . Pflugers Arch. 2016;468:1207-14.

Seidel T, Edelmann JC, Sachse FB . Analyzing Remodeling of Cardiac Tissue: A Comprehensive Approach Based on Confocal Microscopy and 3D Reconstructions . Ann Biomed Eng. 2016.

Franklin S, Kimball T, Rasmussen TL, M. Garrido R, Chen H, Tran T, Miller MR, Gray R, Jiang S, Ren S, Wang Y, Tucker HO, Vondriska TM . The chromatin binding protein Smyd1 restricts adult mammalian heart growth. Am J Physiol Heart Circ Physiol. 2016:ajpheart 00235 2016. Google Scholar


Abdullah OM, Seidel T, Dahl M, Gomez AD, Yiep G, Cortino J, Sachse FB, Albertine KH, Hsu EW . Diffusion tensor imaging and histology of developing hearts. NMR Biomed. 2016. Google Scholar

Winters AA, Bou-Ghannam S, Thorp H, Hawayek JA, Atkinson DL, Bartlett CE, Silva FJ, Hsu EW, Moreno AP, Grainger DA, Patel AN . Evaluation of Multiple Biological Therapies for Ischemic Cardiac Disease. Cell Transplant. 2016. Google Scholar

Velinder M, Singer J, Bareyan D, Meznarich J, Tracy CM, Fulcher JM, McClellan D, Lucente H, Franklin S, Sharma S, Engel ME . GFI1 functions in transcriptional control and cell fate determination require SNAG domain methylation to recruit LSD1. Biochem J. 2016;473:3355-69. Google Scholar

Wu W, Gardner A, Sachse F, Sanguinetti M . Ginsenoside Rg3, a gating modifier of EAG family K+ channels. Mol Pharmacol. 2016. Google Scholar

Suzuki T, Hansen A, Sanguinetti MC . Hydrophobic interactions between the S5 segment and the pore helix stabilizes the closed state of Slo2.1 potassium channels. Biochim Biophys Acta. 2016;1858:783-92. Google Scholar

Polejaeva IA, Ranjan R, Davies CJ, Regouski M, Hall J, Olsen AL, Meng Q, Rutigliano HM, Dosdall DJ, Angel NA, Sachse FB, Seidel T, Thomas AJ, Stott R, Panter KE, Lee PM, AJ VANWett, Stevens JR, Wang Z, MacLeod RS, Marrouche NF, White KL . Increased Susceptibility to Atrial Fibrillation Secondary to Atrial Fibrosis in Transgenic Goats Expressing Transforming Growth Factor-beta1. J Cardiovasc Electrophysiol. 2016. Google Scholar

Lichter J, Li H, Sachse FB . Measurement of Strain in Cardiac Myocytes at Micrometer Scale Based on Rapid Scanning Confocal Microscopy a nd Non-Rigid Image Registration. Ann Biomed Eng. 2016. Google Scholar

Wu W, Sanguinetti MC . Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology. Card Electrophysiol Clin. 2016;8:275-84. Google Scholar

Moreno-Galindo EG, Sanchez-Chapula JA, Tristani-Firouzi M, Navarro-Polanco RA . Pharmacological Conversion of a Cardiac Inward Rectifier into an Outward Rectifier Potassium Channel. Mol Pharmacol. 2016;90:334-40. Google Scholar

Monte E, Rosa-Garrido M, Karbassi E, Chen H, Lopez R, Rau CD, Wang J, Nelson SF, Wu Y, Stefani E, Lusis AJ, Wang Y, Kurdistani SK, Franklin S, Vondriska TM . Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf: IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION. J Biol Chem. 2016;291:15428-46. Google Scholar

Huang C, Sachse FB, Hitchcock RW, Kaza AK . Sensitivity and Specificity of Cardiac Tissue Discrimination Using Fiber-Optics Confocal Microscopy. PLoS One. 2016;11:e0147667. Google Scholar

Aras K, Burton B, Swenson D, MacLeod R . Spatial organization of acute myocardial ischemia. J Electrocardiol. 2016;49:323-36. Google Scholar

 

2015

Garg V, Taylor TG, Warren M, Venable PW, Sciuto KJ, Shibayama J, Zaitsev AV . beta-Adrenergic Stimulation and Rapid Pacing Mutually Promote Heterogeneous Electrical Failure and Ventricular Fibrillation in the Globally Ischemic Heart. Am J Physiol Heart Circ Physiol. 2015. Google Scholar

Li H, Lichter JG, Seidel T, Tomaselli GF, Bridge JH, Sachse FB . Cardiac Resynchronization Therapy Reduces Subcellular Heterogeneity of Ryanodine Receptors, T-Tubules and Ca2+ Sparks Produced by Dyssynchronous Heart Failure. Circ Heart Fail. 2015. Google Scholar

Gardner A, Sanguinetti MC . C-Linker Accounts for Differential Sensitivity of ERG1 and ERG2 K+ Channels to RPR260243-Induced Slow Deactivation. Mol Pharmacol. 2015;88:19-28. Google Scholar

Wu W, Gardner A, Sanguinetti MC . Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243. Mol Pharmacol. 2015;87:401-9. Google Scholar

Salameh A, Halling M, Seidel T, Dhein S . Effects of minocycline on parameters of cardiovascular recovery after cardioplegic arrest in a rabbit Langendorff heart model. Clin Exp Pharmacol Physiol. 2015. Google Scholar

Wemhöner K, Friedrich C, Stallmeyer B, Coffey AJ, Grace A, Zumhagen S, Seebohm G, Ortiz-Bonnin B, Rinné S, Sachse FB, Schulze-Bahr E, Decher N . Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome. J Mol Cell Cardiol. 2015;80. Google Scholar

Thomson SJ, Hansen A, Sanguinetti MC . Identification of the Intracellular Na+ Sensor in Slo2.1 Potassium Channels. J Biol Chem. 2015. Google Scholar

Wu W, Gardner A, Sanguinetti MC . The Link between Inactivation and High Affinity Block of hERG1 Channels. Mol Pharmacol. 2015. Google Scholar

Shibayama J, Yuzyuk TN, Cox J, Makaju A, Miller M, Lichter J, Li H, Leavy JD, Franklin S, Zaitsev AV . Metabolic Remodeling in Moderate Synchronous versus Dyssynchronous Pacing-Induced Heart Failure: Integrated Metabolomics and Proteomics Study. PLoS One. 2015;10(3). Google Scholar

Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HD, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, Vondriska TM, Hajnoczky G, Kwon O, Chen JN . Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Elife. 2015;4. Google Scholar

Venable PW, Sciuto KJ, Warren M, Taylor TG, Garg V, Shibayama J, Zaitsev AV . Mitochondrial depolarization and asystole in the globally ischemic rabbit heart: coordinated response to interventions affecting energy balance. Am J Physiol Heart Circ Physiol. 2015;308(5). Google Scholar

Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, Sipido KR, Xie ZJ . Na(+) /Ca(2+) exchange and Na(+) /K(+) -ATPase in the heart. J Physiol. 2015;593(6). Google Scholar

Swietach P, Spitzer KW, Vaughan-Jones RD . Na(+) ions as spatial intracellular messengers for co-ordinating Ca(2)(+) signals during pH heterogeneity in cardiomyocytes. Cardiovasc Res. 2015;105(2). Google Scholar

Radwanski PB, Brunello L, Veeraraghavan R, Ho HT, Lou Q, Makara MA, Belevych AE, Anghelescu M, Priori SG, Volpe P, Hund TJ, Janssen PM, Mohler PJ, Bridge JH, Poelzing S, Gyorke S . Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release. Cardiovasc Res. 2015;106(1). Google Scholar

Holt-Casper D, Theisen JM, Moreno AP, Warren M, Silva F, Grainger DW, Bull DA, Patel AN . Novel xeno-free human heart matrix-derived three-dimensional scaffolds. J Transl Med. 2015;13. Google Scholar

Mondal A, Baker B, Harvey IR, Moreno AP . PerFlexMEA: a thin microporous microelectrode array for in vitro cardiac electrophysiological studies on hetero-cellular bilayers with controlled gap junction communication. Lab Chip. 2015. Google Scholar

Diakos NA, Selzman CH, Stehlik J, Sachse FB, Kfoury AG, Koliopoulou A, McKellar S, Fang JC, Li DY, Drakos SG . Reply: does size matter? In search of a physiological definition of myocardial atrophy. J Am Coll Cardiol. 2015;65:2156-7. Google Scholar

Plimpton RL, Cuellar J, Lai CW, Aoba T, Makaju A, Franklin S, Mathis AD, Prince JT, Carrascosa JL, Valpuesta JM, Willardson BM . Structures of the Gbeta-CCT and PhLP1-Gbeta-CCT complexes reveal a mechanism for G-protein beta-subunit folding and Gbetagamma dimer assembly. Proc Natl Acad Sci U S A. 2015;112(8). Google Scholar

 

2014

Lux RL, Sower CT, Allen N, Etheridge SP, Tristani-Firouzi M, Saarel EV . The application of root mean square electrocardiography (RMS ECG) for the detection of acquired and congenital long QT syndrome. PloS one. 2014;9(1). Google Scholar

Zaniboni M, Cacciani F, Lux RL . Beat-to-Beat Cycle Length Variability of Spontaneously Beating Guinea Pig Sinoatrial Cells: Relative Contributions of the Membrane and Calcium Clocks. PLoS ONE. 2014;9(6):e100242. Google Scholar

Abdullah OM, Drakos SG, Diakos NA, Wever-Pinzon O, Kfoury AG, Stehlik J, Selzman CH, Reid BB, Brunisholz K, Verma DR, Myrick C, Sachse FB, Li DY, Hsu EW . Characterization of diffuse fibrosis in the failing human heart via diffusion tensor imaging and quantitative histological validation. NMR Biomed. 2014;27(11). Google Scholar

Thomson SJ, Hansen A, Sanguinetti MC . Concerted all-or-none subunit interactions mediate slow deactivation of human ether-a-go-go-related gene K+ channels. J Biol Chem. 2014;289(34):23428-36. Google Scholar

Wu W, Gardner A, Sanguinetti MC . Cooperative subunit interactions mediate fast C-type inactivation of hERG1 K+ channels. J Physiol. 2014;592(Pt 20). Google Scholar

Riedel M, Jou CJ, Lai S, Lux RL, Moreno AP, Spitzer KW, Christians E, Tristani-Firouzi M, Benjamin IJ . Functional and pharmacological analysis of cardiomyocytes differentiated from human peripheral blood mononuclear-derived pluripotent stem cells. Stem Cell Reports. 2014;3:131-41. Google Scholar

Sanguinetti MC . HERG1 channel agonists and cardiac arrhythmia. Curr Opin Pharmacol. 2014;15:22-7. Google Scholar

Garg P, Sanguinetti MC . Intracellular ATP does not inhibit Slo2.1 K+ channels. Physiol Rep. 2014;2(9). Google Scholar

Huang C, Kaza AK, Hitchcock RW, Sachse FB . Local delivery of fluorescent dye for fiber-optics confocal microscopy of the living heart. Front Physiol. 2014;5. Google Scholar

Torres NS, Sachse FB, Izu LT, Goldhaber JI, Spitzer KW, Bridge JH . A modified local control model for Ca2+ transients in cardiomyocytes: junctional flux is accompanied by release from adjacent non-junctional RyRs. J Mol Cell Cardiol. 2014;68:1-11. Google Scholar

Diakos NA, Selzman CH, Sachse FB, Stehlik J, Kfoury AG, Wever-Pinzon O, Catino A, Alharethi R, Reid BB, Miller DV, Salama M, Zaitsev AV, Shibayama J, Li H, Fang JC, Li DY, Drakos SG . Myocardial atrophy and chronic mechanical unloading of the failing human heart: implications for cardiac assist device-induced myocardial recovery. J Am Coll Cardiol. 2014;64(15). Google Scholar

Lopez-Izquierdo A, Warren M, Riedel M, Cho S, Lai S, Lux RL, Spitzer KW, Benjamin IJ, Tristani-Firouzi M, Jou CJ . A near-infrared fluorescent voltage-sensitive dye allows for moderate-throughput electrophysiological analyses of human induced pluripotent stem cell-derived cardiomyocytes. Am J Physiol Heart Circ Physiol. 2014;307:H1370-7. Google Scholar

Swietach P, Leem CH, Spitzer KW, Vaughan-Jones RD . Pumping Ca2+ ions up H+ gradients: a cytoplasmic Ca2+/H+ exchanger without a membrane. J Physiol. 2014. Google Scholar

Dhein S, Seidel T, Salameh A, Jozwiak J, Hagen A, Kostelka M, Hindricks G, Mohr FW . Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias. 2014;5:424. Google Scholar

Lichter JG, Carruth E, Mitchell C, Barth AS, Aiba T, Kass DA, Tomaselli GF, Bridge JH, Sachse FB . Remodeling of the sarcomeric cytoskeleton in cardiac ventricular myocytes during heart failure and after cardiac resynchronization therapy. J Mol Cell Cardiol. 2014;72C:186-195. Google Scholar

Salameh A, Haunschild J, Brauchle P, Peim O, Seidel T, Reitmann M, Kostelka M, Bakhtiary F, Dhein S, Dahnert I . On the Role of the Gap Junction Protein Cx43 (GJA1) in Human Cardiac Malformations with Fallot-Pathology. A Study on Paediatric Cardiac Specimen. PLoS One. 2014;9:e95344. Google Scholar

Aras K, Burton B, Swenson D, MacLeod R . Sensitivity of epicardial electrical markers to acute ischemia detection. J Electrocardiol. 2014;47:836-41. Google Scholar

Wu W, Sachse FB, Gardner A, Sanguinetti MC . Stoichiometry of altered hERG1 channel gating by small molecule activators. J Gen Physiol. 2014;143:499-512. Google Scholar

Kumar PP, Franklin S, Emechebe U, Hu H, Moore B, Lehman C, Yandell M, Moon AM . TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome. PLoS Genet. 2014;10:e1004247. Google Scholar

Kumar PP, Franklin S, Emechebe U, Hu H, Moore B, Lehman C, Yandell M, Moon AM . TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome. PLoS Genet. 2014;10:e1004247. Google Scholar

 

2013

Samson SC, Ferrer T, Jou CJ, Sachse FB, Shankaran SS, Shaw RM, Chi NC, Tristani-Firouzi M, Yost HJ . 3-OST-7 regulates BMP-dependent cardiac contraction. PLoS Biol. 2013;11:e1001727. Google Scholar

Sohn K, Wende AR, Abel ED, Moreno AP, Sachse FB, Punske BB . Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia. Exp Physiol. 2013;98:746-57. Google Scholar

Seidel T, Hammer N, Garnov N, Schneider G, Steinke H . An algorithm for the calculation of three-dimensional collagen fiber orientation in ligaments using angle-sensitive MRI. Magn Reson Med. 2013;69:1595-602. Google Scholar

Zhang XQ, Tang R, Li L, Szucsik A, Javan H, Saegusa N, Spitzer KW, Selzman CH . Cardiomyocyte-specific p65 NF-kappaB deletion protects the injured heart by preservation of calcium handling. Am J Physiol Heart Circ Physiol. 2013;305:H1089-97. Google Scholar

Swietach P, Youm JB, Saegusa N, Leem CH, Spitzer KW, Vaughan-Jones RD . Coupled Ca2+/H+ transport by cytoplasmic buffers regulates local Ca2+ and H+ ion signaling. PNAS 2013. 2013:10. Google Scholar

Steinke K, Sachse F, Ettischer N, Strutz-Seebohm N, Henrion U, Rohrbeck M, Klosowski R, Wolters D, Brunner S, Franz WM, Pott L, Munoz C, Kandolf R, Schulze-Bahr E, Lang F, Klingel K, Seebohm G . Coxsackievirus B3 modulates cardiac ion channels. FASEB J. 2013;27:4108-21. Google Scholar

Venable PW, Taylor TG, Sciuto KJ, Zhao J, Shibayama J, Warren M, Spitzer KW, Zaitsev AV . Detection of mitochondrial depolarization/recovery during ischaemia--reperfusion using spectral properties of confocally recorded TMRM fluorescence. J Physiol. 2013;591:2781-94. Google Scholar

Ragone MI, Torres NS, Consolini AE . Energetic study of cardioplegic hearts under ischaemia/reperfusion and [Ca(2+)] changes in cardiomyocytes of guinea-pig: mitochondrial role. Acta Physiol (Oxf). 2013;207:369-84. Google Scholar

Ajijola OA, Vaseghi M, Zhou W, Yamakawa K, Benharash P, Hadaya J, Lux RL, Mahajan A, Shivkumar K . Functional differences between junctional and extrajunctional adrenergic receptor activation in mammalian ventricle. Am J Physiol Heart Circ Physiol. 2013;304:H579-88. Google Scholar

Garg V, Stary-Weinzinger A, Sanguinetti MC . ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels. Mol Pharmacol. 2013;83:805-13. Google Scholar

Huang C, Kaza AK, Hitchcock RW, Sachse FB . Identification of nodal tissue in the living heart using rapid scanning fiber-optics confocal microscopy and extracellular fluorophores. Circ Cardiovasc Imaging. 2013;6:739-46. Google Scholar

Jou CJ, Barnett SM, Bian JT, Weng HC, Sheng X, Tristani-Firouzi M . An in vivo cardiac assay to determine the functional consequences of putative long QT syndrome mutations. Circ Res. 2013;112:826-30. Google Scholar

Shibayama J, Taylor TG, Venable PW, Rhodes NL, Gil RB, Warren M, Wende AR, Abel ED, Cox J, Spitzer KW, Zaitsev AV . Metabolic determinants of electrical failure in ex-vivo canine model of cardiac arrest: evidence for the protective role of inorganic pyrophosphate. PLoS One. 2013;8:e57821. Google Scholar

Saegusa N, Garg V, Spitzer KW . Modulation of ventricular transient outward K(+) current by acidosis and its effects on excitation-contraction coupling. Am J Physiol Heart Circ Physiol. 2013;304:H1680-96. Google Scholar

Veeraraghavan R, Larsen AP, Torres NS, Grunnet M, Poelzing S . Potassium channel activators differentially modulate the effect of sodium channel blockade on cardiac conduction. Acta Physiol (Oxf). 2013;207:280-9. Google Scholar

Lu G, Ota A, Ren S, Franklin S, Rau CD, Ping P, Lane TF, Zhou ZH, Reue K, Lusis AJ, Vondriska T, Wang Y . PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response. Mol Metab. 2013;2:405-16. Google Scholar

Schwab BC, Seemann G, Lasher RA, Torres NS, Wulfers EM, Arp M, Carruth ED, Bridge JH, Sachse FB . Quantitative analysis of cardiac tissue including fibroblasts using three-dimensional confocal microscopy and image reconstruction: towards a basis for electrophysiological modeling. IEEE Trans Med Imaging. 2013;32:862-72. Google Scholar

Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MS, Sanguinetti MC, Baukrowitz T, Decher N . Side pockets provide the basis for a new mechanism of Kv channel-specific inhibition. Nat Chem Biol. 2013;9:507-13. Google Scholar

Garg P, Gardner A, Garg V, Sanguinetti MC . Structural basis of ion permeation gating in Slo2.1 K+ channels. J Gen Physiol. 2013;142:523-42. Google Scholar

Monte E, Mouillesseaux K, Chen H, Kimball T, Ren S, Wang Y, Chen JN, Vondriska TM, Franklin S . Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2013;305:H1624-38. Google Scholar
Chen H, Monte E, Vondriska TM, Franklin S . Systems proteomics of healthy and diseased chromatin. Methods Mol Biol. 2013;1005:77-93. Google Scholar

Navarro-Polanco RA, Arechiga-Figueroa IA, Salazar-Fajardo PD, Benavides-Haro DE, Rodriguez-Elias JC, Sachse FB, Tristani-Firouzi M, Sanchez-Chapula JA, Moreno-Galindo EG . Voltage sensitivity of M2 muscarinic receptors underlies the delayed rectifier-like activation of ACh-gated K+ current by choline in feline atrial myocytes. J Physiol. 2013;591:4273-86. Google Scholar

Ajijola OA, Yagishita D, Patel KJ, Vaseghi M, Zhou W, Yamakawa K, So E, Lux RL, Mahajan A, Shivkumar K. Focal myocardial infarction induces global remodeling of cardiac sympathetic innervation: neural remodeling in a spatial context. Am J Physiol Heart Circ Physiol. 2013 305(7):H1031-1040.

Vaseghi M, Yamakawa K, Sinha A, So EL, Zhou W, Ajijola OA, Lux RL, Laks M, Shivkumar K, Mahajan A. Modulation of regional dispersion of repolarization and T-peak to T-end interval by the right and left stellate ganglia. Am J Physiol Heart Circ Physiol. 2013 305(7):H1020-1030.

2012

Wulfers EM, Torres NS, Lenis G, Li H, Seemann G, Dössel O, Bridge JHB, Sachse FB . An automated approach to analyze microstructural remodeling from confocal microscopies of ventricular myocytes from diseased hea rts. Biomed Tech (Berl). 2012;57:46-49. Google Scholar

Blaufox AD, Tristani-Firouzi M, Seslar S, Sanatani S, Trivedi B, Fischbach P, Paul T, Young ML, Tisma-Dupanovic S, Silva J, Cuneo B, Fournier A, Singh H, Tanel RE, Etheridge SP . Congenital Long QT 3 in the Pediatric Population. Am J Cardiol. 2012;109:1459-65. Google Scholar

Lasher RA, Pahnke AQ, Johnson JM, Sachse FB, Hitchcock RW . Electrical stimulation directs engineered cardiac tissue to an age-matched native phenotype. J Tissue Eng. 2012;3. Google Scholar

Mitchell-Jordan S, Chen H, Franklin S, Stefani E, Bentolila LA, Vondriska TM . Features of endogenous cardiomyocyte chromatin revealed by super-resolution STED microscopy. J Mol Cell Cardiol. 2012;53:552-8. Google Scholar

Christophersen IE, Olesen MS, Liang B, Andersen MN, Larsen AP, Nielsen JB, Haunsø S, Olesen SP, Tveit A, Svendsen JH, Schmitt N . Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation. Eur Heart J. 2012. Google Scholar

Franklin S, Vondriska TM . Genomes, proteomes, and the central dogma. Circulation Cardiovasc Genet. 2012;4:576. Google Scholar

Veeraraghavan R, Salama ME, Poelzing S . Interstitial Volume Modulates the Conduction Velocity- Gap Junction Relationship. Am J Physiol Heart Circ Physiol. 2012;302:H278-86. Google Scholar

Frank DU, Carter KL, Thomas KR, Burr RM, Bakker ML, W.A. C, Tristani-Firouzi M, Bamshad MJ, Christoffels VM, Moon AM . Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis . Proc Natl Acad Sci U S A. 2012;109:E154-63. Google Scholar

Twiner MJ, Doucette GJ, Rasky A, Huang XP, Roth BL, Sanguinetti MC . Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels. Chem Res Toxicol. 2012;25:1975-84. Google Scholar

McNary TG, Spitzer KW, Holloway H, Bridge JHB, Kohl P, Sachse FB . Mechanical modulation of the transverse tubular system of ventricular cardiomyocytes. Prog Biophys Mol Biol. 2012;110:218-225. Google Scholar

Kekenes-Huskey PM, Cheng Y, Hake JE, Sachse FB, Bridge JH, Holst MJ, McCammon JA, McCulloch AD, Michailova AP . Modeling effects of l-type Ca2+ current and Na+-Ca2+ exchanger on Ca2+ trigger flux in rabbit myocytes with realistic t-tubule geometries. Front Physiol. 2012. Google Scholar

Monte E, Chen H, Kolmakova M, Parvatiyar M, Vondriska TM, Franklin S . Quantitative analysis of chromatin proteomes in disease. J Vis Exp. 2012. Google Scholar

Franklin S, Chen H, Mitchell-Jordan SA, Ren S, Wang Y, Vondriska TM . Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth. Mol Cell Proteomics. 2012. Google Scholar

Taylor TG, Venable PW, Shibayama J, Warren JW, Zaitsev AV . Role of KATP Channel in Electrical Depression and Asystole during Long-Duration Ventricular Fibrillation in Ex-Vivo Canine Heart . Am J Physiol Heart Circ Physiol. 2012. Google Scholar

Seidel T, Draebing T, Seemann G, Sachse FB . A Semi-automatic Approach for Segmentation of Three-Dimensional Microscopic Image Stacks of Cardiac Tissue. Functional Imaging and Modeling of the Heart. 2012; 7945:300-307. doi:10.1007/978-3-642-38899-6_36.

Chen H, Monte E, Parvatiyar MS, Rosa-Garrido M, Franklin S, Vondriska TM . Structural considerations for chromatin state models with transcription as a functional readout. FEBS Lett. 2012;586:3548-54. Google Scholar

Garg P, Sanguinetti MC . Structure-activity relationship of fenamates as Slo2.1 channel activators. Mol Pharmacol. 2012;82:795-802. Google Scholar

Sachse FB, Torres NS, Savio-Galimberti E, Aiba T, Kass DA, Tomaselli GF, Bridge JH . Subcellular structures and function of myocytes impaired during heart failure are restored by cardiac resynchronization therapy. Circ Res. 2012;110:588-597. Google Scholar

Vaseghi M, Lux RL, Mahajan A, Shivkumar K . Sympathetic Stimulation Increases Dispersion of Repolarization in Humans with Myocardial Infarction. Am J Physiol Heart Circ Physiol. 2012. Google Scholar

Garg V, Sachse FB, Sanguinetti M . Tuning of EAG K+ channel inactivation: molecular determinants of amplification by mutations and a small molecule. J Gen Physiol. 2012;140:307-24. Google Scholar

Rigby JR, Poelzing S . A novel frequency analysis method for assessing K(ir)2.1 and Na (v)1.5 currents. Ann Biomed Eng. 2012;40:946-954. Google Scholar

Larsen AP, Sciuto KJ, Moreno AP, Poelzing S . The voltage-sensitive dye di-4-ANEPPS slows conduction velocity in isolated guinea pig hearts. Heart Rhythm. 2012. Google Scholar

2011

Fink M, Niederer SA, Cherry EM, Fenton FH, Koivumaki JT, Seemann G, Thul R, Zhang H, Sachse FB, Beard D, Crampin EJ, Smith NP . Cardiac cell modelling: observations from the heart of the cardiac physiome project. Prog Biophys Mol Biol. 2011;104:2-21. Google Scholar
Navarro-Polanco RA, Galindo EGMoreno, Ferrer-Villada T, Arias M, Rigby JR, Sanchez-Chapula JA, Tristani-Firouzi M . Conformational changes in the M2 muscarinic receptor induced by membrane voltage and agonist binding. J Physiol. 2011. Google Scholar

Dhein S, Rothe S, Busch A, Gomez DMRojas, Boldt A, Reutemann A, Seidel T, Salameh A, Pfannmuller B, Rastan A, Kostelka M, Mohr FW . Effects of metoprolol therapy on cardiac gap junction remodelling and conduction in human chronic atrial fibrillation. Br J Pharmacol. 2011;164:607-16. Google Scholar

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Decher N, Wemhöner K, Rinné S, Netter MF, Zuzarte M, Aller MI, Kaufmann SG, Li XT, Meuth SG, Daut J, Sachse FB, Maier SK . Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex. Cell Physiol Biochem. 2011;28:77-86. Google Scholar

Sheets MF, Chen T, Hanck DA . Lidocaine Partially Depolarizes the S4 Segment in Domain IV of the Sodium Channel. European Journal of Physiology. 2011;461:91-97. Google Scholar

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Clayton RH, Bernus O, Cherry EM, Dierckx H, Fenton FH, Mirabella L, Panfilov AV, Sachse FB, Seemann G, Zhang H . Models of cardiac tissue electrophysiology: progress, challenges and open questions. Prog Biophys Mol Biol. 2011;104:22-48. Google Scholar

Ferrer T, Cordero-Morales JF, Arias M, Ficker E, Medovoy D, Perozo E, Tristani-Firouzi M . Molecular Coupling in the Human ether-a-go-go-related gene-1 (hERG1) K+ Channel Inactivation Pathway. J Biol Chem. 2011;286:39091-9. Google Scholar

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Garg V, Stary-Weinzinger A, Sachse F, Sanguinetti MC . Molecular determinants for activation of human ether-a-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide. Mol Pharmacol. 2011;80:630-7. Google Scholar

Grunnet M, Abbruzzese J, Sachse FB, Sanguinetti MC . Molecular determinants of human ether-a-go-go-related gene 1 (hERG1) K+ channel activation by NS1643. Mol Pharmacol. 2011;79:1-9. Google Scholar

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Lackey DP, Carruth ED, Lasher RA, Boenisch J, Sachse FB, Hitchcock RW . Three-dimensional modeling and quantitative analysis of gap junction distributions in cardiac tissue. Ann Biomed Eng. 2011;39:2683-94. Google Scholar

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Niederer SA, Kerfoot E, Benson AP, Bernabeu MO, Bernus O, Bradley C, Cherry EM, Clayton R, Fenton FH, Garny A, Heidenreich E, Land S, Maleckar M, Pathmanathan P, Plank G, Rodríguez JF, Roy I, Sachse FB, Seemann G, Skavhaug O, Smith NP . Verification of cardiac tissue electrophysiology simulators using an N-version benchmark. Philos Transact A Math Phys Eng Sci. 2011;369:4331-4351. Google Scholar

Niederer SA, Kerfoot E, Benson AP, Bernabeu MO, Bernus O, Bradley C, Cherry EM, Clayton R, Fenton FH, Garny A, Heidenreich E, Land S, Maleckar M, Pathmanathan P, Plank G, Rodriguez JF, Roy I, Sachse FB, Seemann G, Skavhaug O, Smith NP . Verification of cardiac tissue electrophysiology simulators using an N-version benchmark. Philos Trans A Math Phys Eng Sci. 2011;369:4331-51. Google Scholar

2010

Larbig R, Torres N, Bridge JH, Goldhaber JI, Philipson KD . Activation of reverse Na+-Ca2+ exchange by the Na+ current augments the cardiac Ca2+ transient: evidence from NCX knockout mice. J Physiol. 2010;588:3267-76. Google Scholar

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Kozoriz MG, Bechberger JF, Bechberger GR, Suen MW, Moreno AP, Maass K, Willecke K, Naus CC . The connexin43 C-terminal region mediates neuroprotection during stroke. J Neuropathol Exp Neurol. 2010;69:196-206. Google Scholar

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Finlay DD, Nugent CD, Donnelly MP, Lux RL . Eigenleads: ECG leads for maximizing information capture and improving SNR. IEEE Trans Inf Technol Biomed. 2010;14:69-78. Google Scholar

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Larsen AP . Role of ERG1 isoforms in modulation of ERG1 channel trafficking and function. Pflugers Arch. 2010;460:803-12. Google Scholar

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2009

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Poelzing S .   Are electrophysiologically distinct M-cells a characteristic of the wedge preparation?.   Heart Rhythm. 2009;6:1035-7. Google Scholar

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Hamdan MH .   Hemodynamic monitoring during syncope: utility and limitations.   J Cardiovasc Electrophysiol. 2009;20:82-4. Google Scholar

Vaughan-Jones RD,   Spitzer KW,   Swietach P .   Intracellular pH regulation in heart.   J Mol Cell Cardiol. 2009;46:318-331. Google Scholar

Goldhaber JI,   Bridge JH .   Loss of intracellular and intercellular synchrony of calcium release in systolic heart failure.   Circ Heart Fail. 2009;2:157-9. Google Scholar

Sachse FB,   Moreno AP,   Seemann G,   Abildskov JA .   A model of electrical conduction in cardiac tissue including fibroblasts.   Ann Biomed Eng. 2009;37:874-89. Google Scholar

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Weiss DL,   Ifland M,   Sachse FB,   Seemann G,   Dössel O .   Modeling of cardiac ischemia in human myocytes and tissue including spatiotemporal electrophysiological variations.   Biomed Tech (Berl). 2009;54:107-25. Google Scholar

Poelzing S,   Rosenbaum DS .   The modulated dispersion hypothesis confirmed in humans.   Circ Arrhythm Electrophysiol. 2009;2:100-1. Google Scholar

Wasmund SL,   Pai RK,   Freedman RA,   Abedin M,   Daccarett M,   Segerson NM,   Zaitsev AV,   Hamdan MH .   Modulation of the sinus rate during ventricular fibrillation.   J Cardiovasc Electrophysiol. 2009;20:187-92. Google Scholar

Cheng L,   Sanguinetti MC .   Niflumic acid alters gating of HCN2 pacemaker channels by interaction with the outer region of S4 voltage sensing domains.   Mol Pharmacol. 2009. Google Scholar

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Singh H,   Warburton S,   Vondriska TM,   Khakh BS .   Proteomics to identify proteins interacting with P2X2 ligand-gated cation channels.   J Vis Exp. 2009;18. Google Scholar

Sachse FB,   Seemann G .   Special issue: Functional imaging and modelling of the heart.   Med Image Anal. 2009;13:345. Google Scholar

Metcalf CS,   Poelzing S,   Little JG,   Bealer SL .   Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats.   Am J Physiol Heart Circ Physiol. 2009;297:H2120-7.

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Lasher RA,   Hitchcock RW,   Sachse FB .   Towards modeling of cardiac micro-structure with catheter-based confocal microscopy: a novel approach for dye delivery and tissue characterization.   IEEE Trans Med Imaging. 2009;28:1156-64. Google Scholar

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2008

Karabsheh S,   Neuharth RM,   Hamdan MH,   Michaels AD .   Acoustic cardiographic recording during ventricular fibrillation.   Resuscitation. 2008;78:374-7. Google Scholar

Segerson NM,   Wasmund SL,   Daccarett M,   Fabela ML,   Hammond CH,   Stoddard G,   Smith ML,   Hamdan MH .   The acute effect of atrioventricular pacing on sympathetic nerve activity in patients with normal and depressed left ventricular function.   Am J Physiol Heart Circ Physiol. 2008;295:H1076-H1080. Google Scholar

Sobie EA,   Cannell MB,   Bridge JH .   Allosteric activation of Na+-Ca+ exchange by L-typ[e Ca2+ current augments the trigger flux for SR Ca2+ release in ventricular myocytes.   Biophys J. 2008:L54-L56. Google Scholar

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Lux RL,   Kornreich F .   Crossroads in electrocardiographic lead development: a roadmap to the future of electrocardiographic leads in clinical electrocardiography.   J Electrocardiol. 2008;41:183-6. Google Scholar

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Sachse FB,   Moreno AP,   Abildskov JA .   Electrophysiological modeling of fibroblasts and there interaction with myocytes.   Ann Biomed Eng. 2008;36:41-56. Google Scholar

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Sutherland DR,   Ni Q,   MacLeod RS,   Lux RL,   Punske BB .   Experimental measures of ventricular activation and synchrony.   Pacing Clin Electrophysiol. 2008;31:1560-70. Google Scholar

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Sandhu RK,   Costantini O,   Cummings JE,   Poelzing S,   Rosenbaum DS,   Quan KJ .   Intracardiac alternans compared to surface T-wave alternans as a predictor of ventricular arrhythmias in humans.   Heart Rhythm. 2008;5:1003-8. Google Scholar

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Mitchell-Jordan SA,   Holopainen T,   Ren S,   Wang S,   Warburton S,   Zhang MJ,   Alitalo K,   Wang Y,   Vondriska TM .   Loss of Bmx non-receptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy.   Circ Res. 2008;103:1359-62. Google Scholar

Restier L,   Cheng L,   Sanguinetti M .   Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of Iks channels.   J Physiol. 2008;586:4179-4191. Google Scholar

Veeraraghavan R,   Poelzing S .   Mechanisms underlying increased right ventricular conduction sensitivity to flecainide challenge. Cardiovasc Res. 2008;77:749-56. Google Scholar

P. Franzone C,   Pavarino LF,   Scacchi S,   Taccardi B .   Modeling ventricular repolarization: effects of transmural and apex-to-base heterogeneities in action potential durations.   Math Biosci. 2008;214:140-52. Google Scholar

Rodriguez-Menchaca AA,   Navarro-Polanco RA,   Ferrer-Villada T,   Rupp J,   Sachse FB,   Tristani-Firouzi M,   Sanchez-Chapula JA .   The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel.   Proc Natl Acad Sci U S A. 2008;105:1364-1368. Google Scholar

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Wuttke TV,   Penzien J,   Fauler M,   Seebohm G,   Lehmann-Horn F,   Lerche H,   Jurkat-Rott K .   Neutralization of a negative charge in the S1-S2 region of the KV7.2 (KCNQ2) channel affects voltage-dependent activation in neonatal epilepsy.   J Physiol. 2008;586:545-55. Google Scholar

Bridge JH,   Torres NS,   Sobie EA .   New insights into the structure and function of couplons.   J Physiol. 2008;586:3735. Google Scholar

Lux RL .   Noninvasive assessment of cardiac electrophysiology for predicting arrhythmogenic risk: are we getting closer?.   Circulation. 2008;118:899-900. Google Scholar

Savio-Galimberti E,   Frank J,   Inoue M,   Goldhaber JI,   Cannell MB,   Bridge JH,   Sachse FB .   Novel features of the rabbit transverse tubular system revealed by quantitative analysis of three-dimensional reconstructions from confocal images.   Biophys J. 2008;95:2053-62. Google Scholar

Poelzing S,   Smoot AF,   Veeraraghavan R .   Novel x-ray attenuation mechanism: role of interatomic distance.   Med Phys. 2008;35:4386-95. Google Scholar

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2007

Putzke C,   Wemhöner K,   Sachse FB,   Rinné S,   Schlichthörl G,   Lia XT,   Jae L,   Eckhardt I,   Wischmeyer E,   Wulf H,   Preisig-Muller R,   Daut J,   Decher N .   The acid-sensitive potassium channel TASK-1 in rat cardiac muscle.   Cardiovasc Res. 2007;75:59-68.

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Segerson NM,   Sharma N,   Smith ML,   Wasmund SL,   Kowal RC,   Abedin M,  ,   Pai RK,   Freedman RA,   Hamdan MH .   The effects of rate and irregularity on sympathetic nerve activity in human subjects.   Heart Rhythm. 2007;4:20-26. Google Scholar

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Drew BJ,   Schindler DM,   Zegre JK,   Fleischmann KE,   Lux RL .   Estimated body surface potential maps in emergency department patients with unrecognized transient myocardial ischemia.   J Electrocardiol. 2007;40:S15-20. Google Scholar

Sachse FB,   Hunter GA,   Weiss DL,   Seemann G .   A framework for modeling of mechano-electrical feedback mechanisms of cardiac myocytes and tissues.   Conf Proc IEEE Eng Med Biol Soc. 2007;2007:160-3. Google Scholar

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2006

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2005

Moreno AP, Berthoud VM, Perez-Palacios G, Perez-Armendariz EM . Biophysical evidence that connexin-36 forms functional gap junction channels between pancreatic mouse beta-cells. Am J Physiol Endocrinol Metab. 2005;288:E948-56. Google Scholar

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Poelzing S, Dikshteyn M, Rosenbaum DS . Transmural conduction is not a two-way street. J Cardiovasc Electrophysiol. 2005;16:455. Google Scholar

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2004

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Poelzing S, Rosenbaum DS . Nature, significance, and mechanisms of electrical heterogeneities in ventricle. Anat Rec A Discov Mol Cell Evol Biol. 2004;280:1010-7. Google Scholar

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2003

Liu R, Shang Y, Sachse FB, Dössel O . 3D active surface method for segmentation of medical image data: Assessment of different image forces. Biomedizinische Technik. 2003;48:28-29. Google Scholar
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Sachse FB, Seemann G . Modeling of cardiac electro-mechanics in a truncated ellipsoid model of left ventricl. LNCS. 2003;2673:253-260. Google Scholar

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Mohr MB, Blumcke LG, Seemann G, Sachse FB, Dössel O . Modeling of myocardial deformation with an extended spring mass system. Biomedizinische Technik. 2003;48:6-7. Google Scholar
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Sachse FB, Seemann G, Chaisaowong K, Weiss D . Quantitative reconstruction of cardiac electromechanics in human myocardium: assembly of electrophysiologic and tension generation models. J Cardiovasc Electrophysiol. 2003;14:S210-8. Google Scholar

Seemann G, Sachse FB, Weiss DL, Dössel O . Quantitative reconstruction of cardiac electromechanics in human myocardium: regional heterogeneity. J Cardiovasc Electrophysiol. 2003;14:S219-28. Google Scholar

Punske BB, Ni Q, Lux RL, MacLeod RS, Ershler PR, Dustman TJ, Allison MJ, Taccardi B . Spatial methods of epicardial activation time determination in normal hearts. Ann Biomed Eng. 2003;31:781-792. Google Scholar

Huelsing DJ, Spitzer KW, Pollard AE . Spontaneous activity induced in rabbit Purkinje myocytes during coupling to a depolarized model cell. Cardiovasc Res. 2003;In press. Google Scholar

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2002

Scherer CR, Lerche C, Decher N, Dennis AT, Maier P, Ficker E, Busch AE, Wollnik B, Steinmeyer K . The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia. Br J Pharmacol. 2002;137:892-900. Google Scholar

Taccardi B, Punske BB . Body surface and epicardial mapping: State of the art and future perspectives. IJBEM. 2002;4:91-94. Google Scholar

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Sachse FB, Blumcke LG, Mohr M, Glanzel K, Hafner J, Riedel C, Seemann G, Skipa O, Werner CD, Dössel O . Comparison of macroscopic models of excitation and force propagation in the heart. Biomed Tech (Berl). 2002;47 Suppl 1 Pt 1:217-20. Google Scholar

Skipa O, Nalbach M, Sachse FB, Dössel O . Comparison of regularization techniques for the reconstruction of transmembrane potentials in the heart. Biomed Tech (Berl). 2002;47 Suppl 1 Pt 1:246-8. Google Scholar

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Chen T, Sheets MF . Enhancement of closed-state inactivation in long QT syndrome sodium channel mutation DeltaKPQ. Am J Physiol Heart Circ Physiol. 2002;283:H966-75. Google Scholar

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Moreno AP . Filling more gaps: consequences of heterogeneous remodeling in connexin expression. J Cardiovasc Electrophysiol. 2002;13:871-2. Google Scholar

Booker KJ, Drew BJ, Lux RL, Johanson P, Krucoff MW, Hampton D, Hubelbank M, Feild DQ, Stadler RW, Mortara DM . The first ISCE Board of "Trustees" overview panel session: ischemia monitoring, state of the art. International Society of Computerized Electrocardiology. J Electrocardiol. 2002;35 Suppl:207-30. Google Scholar

Berenfeld O, Zaitsev AV, Mironov SF, Pertsov AM, Jalife J . Frequency-dependent breakdown of wave propagation into fibrillatory conduction across the pectinate muscle network in the isolated sheep right atrium. Circ Res. 2002;90:1173-80. Google Scholar

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Guatimosim S, Dilly K, Santana LF, M. Jafri S, Sobie EA, Lederer WJ . Local Ca(2+) signaling and EC coupling in heart: Ca(2+) sparks and the regulation of the [Ca(2+)](i) transient. J Mol Cell Cardiol. 2002;34:941-50. Google Scholar

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Sanchez-Chapula JA, Navarro-Polanco RA, Culberson C, Chen J, Sanguinetti MC . Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block. J Biol Chem. 2002;277:23587-95. Google Scholar

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Sheets MF, Hanck DA . The outermost lysine in the S4 of domain III contributes little to the gating charge in sodium channels. Biophys J. 2002;82:3048-55. Google Scholar

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Sobie EA, Dilly KW, J. Cruz dosSantos, Lederer WJ, Jafri MS . Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release. Biophys J. 2002;83:59-78. Google Scholar

Chen J, Piper DR, Sanguinetti MC . Voltage sensing and activation gating of HCN pacemaker channels. Trends Cardiovasc Med. 2002;12:42-5. Google Scholar

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2001

Sanchez-Chapula JA, Salinas-Stefanon E, Torres-Jacome J, Benavides-Haro DE, Navarro-Polanco RA . Blockade of currents by the antimalarial drug chloroquine in feline ventricular myocytes. J Pharmacol Exp Ther. 2001;297:437-45. Google Scholar

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Jensen DK, Kopeckova P, J.H.B. B, J. K . The cytoplasmic escape and nuclear accumulation of endocytosed and microinjected HPMA copolymers and a basic kinetic study in Hep G2 cells. AAPS PharmSci. 2001;3:E32. Google Scholar

Jensen KD, Kopeckova P, Bridge JH, Kopecek J. The cytoplasmic escape and nuclear accumulation of endocytosed and microinjected HPMA copolymers and a basic kinetic study in Hep G2 cells. AAPS PharmSci. 2001;3:E32. Google Scholar

Decher N, Lang HJ, Nilius B, Bruggemann A, Busch AE, Steinmeyer K. DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br J Pharmacol. 2001;134:1467-79. Google Scholar

MacLeod RS, Yilmaz B, Taccardi B, Punske BB, Serinagaoglu Y, Brooks DH. Direct and inverse methods for cardiac mapping using multielectrode catheter measurements. J Biomedizinishe Technik. 2001;46:207-209. Google Scholar

Cordeiro JM, Bridge JH, Spitzer KW. Early and delayed afterdepolarizations in rabbit heart Purkinje cells viewed by confocal microscopy. Cell Calcium. 2001;29:289-97. Google Scholar

Cordeiro JM, Bridge JHB, Spitzer KW. Early and delayed afterdepolarizations in rabbit heart Purkinje cells viewed by confocal microscopy. Cell Calcium. 2001;29:289-297. Google Scholar

Lux RL, Hilbel T, Brockmeier K. Electrocardiographic measures of repolarization revisited: Why? What? How?. J Electrocardiol. 2001;34:259-264. Google Scholar

Taccardi B, Punske BB, MacLeod RS, Ni Q. Extracardiac effects of myocardial electrical anisotropy. J Biomedizinishe Technik. 2001;46:216-218. Google Scholar

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Elenes S, Martinez AD, Delmar M, Beyer EC, Moreno AP. Heterotypic docking of Cx43 and Cx45 connexons blocks fast voltage gating of Cx43. Biophys J. 2001;81:1406-18. Google Scholar

Decher N, Uyguner O, Scherer CR, Karaman B, Yuksel-Apak M, Busch AE, Steinmeyer K, Wollnik B. hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant. Cardiovasc Res. 2001;52:255-64. Google Scholar

Piper DR, Mujtaba T, Keyoung H, Roy NS, Goldman SA, Rao MS, Lucero MT. Identification and characterization of neuronal precursors and their progeny from human fetal tissue. J Neurosci Res. 2001;66:356-68. Google Scholar

Cordeiro JM, Spitzer KW, Giles WR, Cannell MB, Bridge JHB. Location of the initiation site of calcium transients and sparks in rabbit heart Purkinje cells. J Physiol. 2001;531:301-314. Google Scholar

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Huang FD, Chen J, Lin M, Keating MT, Sanguinetti MC. Long-QT syndrome-associated missense mutations in the pore helix of the HERG potassium channel. Circulation. 2001;104:1071-5. Google Scholar

Fairey ER, Dechraoui MYBottein, Sheets MF, Ramsdell JS. Modification of the cell based assay for brevetoxins using human cardiac voltage dependent sodium channels expressed in HEK-293 cells. Biosens Bioelectron. 2001;16:579-86. Google Scholar

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Burnes JE, Taccardi B, Ershler PR, Rudy Y. Noninvasive electrocardiogram imaging of substrate and intramural ventricular tachycardia in infarcted hearts. J Am Coll Cardiol. 2001;38:2071-8. Google Scholar

Chen-Izu Y, Moreno AP, Spangler RA. Opposing gates model for voltage gating of gap junction channels. Am J Physiol Cell Physiol. 2001;281:C1604-13. Google Scholar

Horacek BM, Warren JW, Penney CJ, MacLeod RS, Title LM, Gardner MJ, Feldman CL. Optimal electrocardiographic leads for detecting acute myocardial ischemia. J Electrocardiol. 2001;34 Suppl:97-111. Google Scholar

MacLeod RS, Punske B, Yilmaz B, Shome S, Taccardi B. The role of heart rate in myocardial ischemia from restricted coronary perfusion. J Electrocardiol. 2001;34 Suppl:43-51. Google Scholar

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Brockmeier K, Aslan I, Hilbel T, , Ulmer HE, Lux RL. T Wave Alternans in LQTS: Repolarization-Rate Dynamics from digital 12 lead Holter data. J Electrocardiol. 2001;34 Supplement:93-96. Google Scholar
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2000

Franzone PCColli, Guerri L, Pennacchio M, Taccardi B. Anisotropic mechanisms for multiphasic unipolar electrograms: simulation studies and experimental recordings. Ann Biomed Eng. 2000;28:1326-42. Google Scholar

Ritter M, Su Z, Spitzer KW, Ishida H, Barry WH. Caffeine-induced Ca(2+) sparks in mouse ventricular myocytes. Am J Physiol Heart Circ Physiol. 2000;278:H666-9. Google Scholar

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Gestenfeld EP, SippensGroeneweggen A, Lux RL, Lesh MD. Derivation of an optimal lead set for measuring ectopic atrial activation from the pulmonary veins using body surface potential mapping. J Electrocardiol. 2000;33:179-185. Google Scholar

Punske BB. Determining the Local Time of Activation from the Unipolar Electrogram: New Methods, New Challenges. J Cardiovasc Electrophysiol. 2000;11:1129-1131. Google Scholar

Sachse FB, Werner CD, Meyer-Waarden K, Dössel O. Development of a human body model for numerical calculation of electrical fields. Comput Med Imaging Graph. 2000;24:165-71. Google Scholar

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MacLeod RS, Ni Q, Punske B, Ershler PR, Yilmaz B, Taccardi B. Effects of heart position on the body-surface electrocardiogram. J Electrocardiol. 2000;33 Suppl:229-37. Google Scholar

Jia P, Punske B, Taccardi B, Rudy Y. Electrophysiologic endocardial mapping from a noncontact nonexpandable catheter: a validation study of a geometry-based concept. J Cardiovasc Electrophysiol. 2000;11:1238-51. Google Scholar

Ping J, Punske BB, Taccardi B, Rudy Y. Electrophysiologic Endocardial Mapping from a Noncontact Nonexpandable Catheter: A Validation Study of Geometry-Based Concept. J Cardiovasc Electrophysiol. 2000;11:1238-1251. Google Scholar

Huelsing DJ, Spitzer KW, Pollard AE. Electrotonic suppression of early afterdepolarizations in isolated rabbit Purkinje myocytes. Am J Physiol Heart Circ Physiol. 2000;279:H250-9. Google Scholar

Fuller MS, Sandor G, Punske B, Taccardi B, MacLeod RS, Ershler PR, Green LS, Lux RL. Estimates of repolarization and its dispersion from electrocardiographic measurements: direct epicardial assessment in the canine heart. J Electrocardiol. 2000;33:171-80. Google Scholar

Fuller MS, Sandor G, Punske BB, Taccardi B, R.S. ML, Ershler PR, Green LS, Lux RL. Estimates of Repolarization and its dispersion from electrocardiographic measurements: Direct epicardial assessment in canine heart. J Electrocardiol. 2000;33:171-180. Google Scholar

Fuller MS, Sandor G, Punske B, Taccardi B, MacLeod RS, Ershler PR, Green LS, Lux RL. Estimates of repolarization dispersion from electrocardiographic measurements. Circulation. 2000;102:685-91. Google Scholar

Zhang J, Bendahhou S, Sanguinetti MC, Ptacek LJ. Functional consequences of chloride channel gene (CLCN1) mutations causing myotonia congenita. Neurology. 2000;54:937-42. Google Scholar

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Piper DR, Mujtaba T, Rao MS, Lucero MT. Immunocytochemical and physiological characterization of a population of cultured human neural precursors. J Neurophysiol. 2000;84:534-48. Google Scholar

Hanck DA, Makielski JC, Sheets MF. Lidocaine alters activation gating of cardiac Na channels. Eur J Physiol. 2000;439:814-821. Google Scholar

Sanguinetti MC. Long QT syndrome: ionic basis and arrhythmia mechanism in long QT syndrome type 1. J Cardiovasc Electrophysiol. 2000;11:710-2. Google Scholar

Sanguinetti MC. Maximal function of minimal K+ channel subunits. Trends Pharmacol Sci. 2000;21:199-201. Google Scholar

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Burnes JE, Taccardi B, MacLeod RS, Rudy Y. Noninvasive ECG imaging of electrophysiologically abnormal substrates in infarcted hearts : A model study. Circulation. 2000;101:533-40. Google Scholar

Burnes JE, Taccardi B, Rudy Y. A noninvasive imaging modality for cardiac arrhythmias. Circulation. 2000;102:2152-8. Google Scholar

Sheets MF, Kyle JW, Hanck DA. The role of the putative inactivation lid in sodium channel gating current immobilization. J Gen Physiol. 2000;115:609-619. Google Scholar

Abildskov JA, Lux RL. Simulated Torsade de Pointes - the role of conduction defects and mechanism of QRS rotation. J Electrocardiol. 2000;33:55-64. Google Scholar

Abildskov JA, Lux RL. Simulated torsade de pointes--the role of conduction defects and mechanism of QRS rotation. J Electrocardiol. 2000;33:55-64. Google Scholar

Mitcheson JS, Chen J, Lin M, Culberson C, Sanguinetti MC. A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci U S A. 2000;97:12329-33. Google Scholar

Wung S-F, Lux RL, Drew BJ. Thoracic location of the lead with maximal ST-segment deviation during posterior and right ventricular ischemia: Comparison of 18-lead ECG with 192 estimated body surfce leads. J Electrocardiol. 2000;33:In press. Google Scholar

Wung SF, Lux RL, Drew BJ. Thoracic location of the lead with maximal ST-segment deviation during posterior and right ventricular ischemia: comparison of 18-lead ECG with 192 estimated body surface leads. J Electrocardiol. 2000;33 Suppl:167-74. Google Scholar

Mitcheson JS, Chen J, Sanguinetti MC. Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate. J Gen Physiol. 2000;115:229-40. Google Scholar

Lux RL. Uncertainty of the electrocardiogram: Old and new ideas for assessment and interpretation. J Electrocardiol. 2000;33:203-208. Google Scholar

Hren R, Steinhoff U, Gessner C, Endt P, Goedde P, Agrawal R, Oeff M, Lux RL, Trahms L. Value of magnetocardiographic QRST integral maps in the identification of patients at risk of ventricular arrhythmias. PACE. 2000;22:1292-304. Google Scholar

 

1999

Mitcheson JS, Sanguinetti MC. Biophysical properties and molecular basis of cardiac rapid and slow delayed rectifier potassium channels. Cell Physiol Biochem. 1999;9:201-16. Google Scholar

Piper DR, Lucero MT. Calcium signalling in squid olfactory receptor neurons. Biol Signals Recept. 1999;8:329-37. Google Scholar

Stafforini DM, Numao T, Tsodikov A, Vaitkus D, Fukuda T, Watanabe N, Fueki N, McIntyre TM, Zimmerman GA, Makino S, Prescott SM. Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma. J Clin Invest. 1999:In press. Google Scholar

Sanguinetti MC. Dysfunction of delayed rectifier potassium channels in an inherited cardiac arrhythmia. Ann N Y Acad Sci. 1999;868:406-13. Google Scholar

Klepfer RN, Johnson CR, MacLeod RS. The effects of inhomogeneities and anisotropies on electrocardiographic fields: A three-dimensional finite element study. IEEE Trans Biomed Eng. 1999;44:706-719. Google Scholar

Zimmerman GA, Albertine KH, Carveth HJ, Gill EA, Grissom CK, Hoidal JR, Imaizumi T-a., Maloney CG, McIntyre TM, Michael JR, Orme JF, Prescott SM, Topham MS. Endothelial activation of ARDS. Chest. 1999;116:18S-24S. Google Scholar

Kuenzler RO, MacLeod RS, Taccardi B, Ni Q, Lux RL. Estimation of epicardial activation maps from intravascular recordings. J Electrocardiol. 1999;32:77-92. Google Scholar

Wang Z, Tristani-Firouzi M, Xu Q, Lin M, Keating MT, Sanguinetti MC. Functional effects of mutations in KvLQT1 that cause long QT syndrome. J Cardiovasc Electrophysiol. 1999;10:817-26. Google Scholar

Sheets MF, Hanck DA. Gating of skeletal and cardiac muscle sodium channels in mammalian cells. J Physiol. 1999;514:425-436. Google Scholar

Brooks DH, Ahmad GF, MacLeod RS, Maratos GM. Inverse electrocardiography by simultaneous imposition of multiple constraints. IEEE Trans Biomed Eng. 1999;46:3-18. Google Scholar

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Chen J, Zou A, Splawski I, Keating MT, Sanguinetti MC. Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation. J Biol Chem. 1999;274:10113-8. Google Scholar
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Punske BB, Lux RL, MacLeod RS, Fuller MS, Ershler PR, Dustman TJ, Vyhmeister Y, Taccardi B. Mechanisms of spatial distribution of QT intervals on the epicardial and body surfaces. J Cardiovasc Electrophysiol. 1999;10:1605-1618. Google Scholar

Punske BB, Lux RL, MacLeod RS, Fuller MS, Ershler PR, Dustman TJ, Vyhmeister Y, Taccardi B. Mechanisms of the spatial distribution of QT intervals on the epicardial and body surfaces. J Cardiovasc Electrophysiol. 1999;10:1605-18. Google Scholar

Huelsing DJ, Spitzer KW, Cordeiro JM, Pollard AE. Modulation of repolarization in rabbit Purkinje and ventricular myocytes coupled by a variable resistance. Am J Physiol. 1999;276:H547-H581. Google Scholar

Stafforini DM, Tjoelker LW, McCormick SPA, Vaitkust D, McIntyre TM, Gray PW, Young SG, Prescott SM. Molecular basis of the interaction between plasma platelet-activating factor acetylhydrolase and low density lipoprotein. J Biol Chem. 1999;274:In press. Google Scholar

Sanguinetti MC, Xu QP. Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes. J Physiol. 1999;514 ( Pt 3):667-75. Google Scholar

Sheets MF, Kyle JW, Kallen RG, Hanck DA. The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4. Biophys J. 1999;77:747-757. Google Scholar

Lux RL, Fuller MS, MacLeod RS, Ershler PR, Punske BB, Taccardi B. Noninvasive indices of repolarization and its dispersion. J Electrocardiol. 1999;32:153-157. Google Scholar

Cheng DK, Tung L, Sobie EA. Nonuniform responses of transmembrane potential during electric field stimulation of single cardiac cells. Am J Physiol. 1999;277:H351-62. Google Scholar

Okazaki O, Lux RL. Paradoxical QRST integral changes with ventricular repolarization dispersion. J Electrocardiol. 1999;32:60-69. Google Scholar

Kralios FA, Cluff N, Anderson FL, Hanson GR, Kralios AC. Postnatal development of peptidergic innervation of the canine heart. J Mol Cell Cardiol. 1999;31:215-225. Google Scholar

Bridge JH, Ershler PR, Cannell MB. Properties of Ca2+ sparks evoked by action potentials in mouse ventricular myocytes. J Physiol. 1999;518 ( Pt 2):469-78. Google Scholar

Lorant DE, Li W, Tabatabaei N, Garver MK, Albertine KH. P-selectin expression by endothelial cells is decreased in neonatal rats and human premature infants. Blood. 1999;94:600-609. Google Scholar

Su Z, Bridge JH, Philipson KD, Spitzer KW, Barry WH. Quantitation of Na/Ca exchanger function in single ventricular myocytes. J Mol Cell Cardiol. 1999;31:1125-35. Google Scholar

Susil RC, Sobie EA, Tung L. Separation between virtual sources modifies the response of cardiac tissue to field stimulation. J Cardiovasc Electrophysiol. 1999;10:715-27. Google Scholar

Ni Q, MacLeod RS, Lux RL. Three-dimensional activation mapping in ventricular muscle: Interpolation and approximation of activation times. Ann Biomed Eng. 1999;27:617-626. Google Scholar

 

1998

Yao A, Su Z, Nonaka A, Zubair I, Spitzer KW, Bridge JH, Muelheims G, Ross, Jr. J, Barry WH. Abnormal myocyte Ca2+ homeostasis in rabbits with pacing-induced heart failure. Am J Physiol. 1998;275:H1441-8. Google Scholar

Johnson CR, MacLeod RS. Adaptive local regularization methods for the inverse ECG problem. Prog Biophys Mol Biol. 1998;69:405-23. Google Scholar

Ahmad GF, Brooks DH, MacLeod RS. An admissible solution approach to inverse electrocardiography. Ann Biomed Eng. 1998;26:278-92. Google Scholar

Abdallah O, Werner CD, Sachse FB, Dössel O. Cellular automated detection for simulation of the impulse transmission with reference to anisotropy. Biomed Tech (Berl). 1998;43 :490-1. Google Scholar

Ding L, Traer E, McIntyre TM, Zimmemran GA, Prescott SM. The cloning and characterization of a novel human diacylglycerol kinase, DGK. J Biol Chem. 1998;273:32746-32752. Google Scholar

Werner CD, Sachse FB, Dössel O. [Comparative assessment of isotropic and anisotropic models of signal transmission in the heart]. Biomed Tech (Berl). 1998;43 Suppl:98-9. Google Scholar

Starck W, Sachse FB, Werner C, Dössel O, Meyer-Waarden K. Comparison of numerically calculated surface potentials with and without considering anisotropic muscle tissue. Biomed Tech (Berl). 1998;43 Suppl:54-5. Google Scholar

Hren R, Punske BB. A comparison of simulated QRS isointegral maps resulting from pacing at adjacent sites: implications for the spatial resolution of pace mapping using body surface potentials. J Electrocardiol. 1998;31:135-144. Google Scholar

Zaniboni M, Yao A, Barry WH, Musso E, Spitzer KW. Complications associated with rapid caffeine application to cardiac myocytes that are not voltage clamped. J Mol Cell Cardiol. 1998;30:2229-2235. Google Scholar
Steingotter A, Werner CD, Sachse FB, Dössel O. Compression of 3- and 4-dimensional medical image data. Biomed Tech (Berl). 1998;43 Suppl:478-9. Google Scholar

Huelsing DJ, Spitzer KW, Cordeiro JM, Pollard AE. Conduction between isolated rabbit Purkinje and ventricular myocytes coupled by a variable resistance. Am J Physiol. 1998;274:H1163-H1173. Google Scholar

Kralios AC, Kralios FA, Anderson FA, Leonard M. Coronary venous hypertension prevents the formation of the electrophysiological arrhythmogenic substrate of acute ischemia in the dog: Salutary effects of preserved myocardial hydration. J Mol Cell Cardiol. 1998;30:255-268. Google Scholar

de Boer IH, Sachse FB, Dössel O. [Development of a 4 camera system for localizing an electrode series on the thorax]. Biomed Tech (Berl). 1998;43 Suppl:56-7. Google Scholar

Yao A, Su Z, Nonaka A, Zubair I, Lu L, Philipson KD, Bridge JH, Barry WH. Effects of overexpression of the Na+-Ca2+ exchanger on [Ca2+]i transients in murine ventricular myocytes. Circ Res. 1998;82:657-65. Google Scholar

Oster HS, Taccardi B, Lux RL, Ershler PR, Rudy Y. Electrocardiographic imaging: Noninvasive characterization of intramural myocardial activation from inverse-reconstructed epicardial potentials and electrograms. Circulation. 1998;97:1496-507. Google Scholar

Liu ZW, Ping J, Biblo LA, Taccardi B, Rudy Y. Endocardial potential mapping from a noncontact nonexpandable catheter: A feasibility study. Ann Biomed Eng. 1998;26:994-100. Google Scholar

Feldhaus MJ, Kessel JM, Zimmerman GA, McIntyre TM. Engagement of ICAM-3 activates polymorphonuclear leukocytes: Aggregation without degranulation or b2 integrin recruitment. J Immunol. 1998;161:6280-6287. Google Scholar

Cao Y, Stafforini DM, Zimmerman GA, McIntyre TM, Prescott SM. Expression of plasma platelet-activating factor acetylhydrolase is transcriptionally regulated by mediators of inflammation. J Biol Chem. 1998;273:4012-4020. Google Scholar

Burnes JE, Kaelber DC, Taccardi B, Lux RL, Ershler PR, Rudy Y. A field-compatible method for interpolating biopotentials. Ann Biomed Eng. 1998;26:37-47. Google Scholar

Perry M, Whyte A. Immunology of the tonsils. Immunol Today. 1998;19:414-21. Google Scholar

Maloney CG, Kutchera WA, K.H. A, McIntyre TM, Prescott SM, Zimmerman GA. Inflammatory agonists induce cyclooxygenase type 2 expression by human neutrophils. J Immunol. 1998;160. Google Scholar

Su Z, Zou A, Nonaka A, Zubair I, Sanguinetti MC, Barry WH. Influence of prior Na+ pump activity on pump and Na+/Ca2+ exchange currents in mouse ventricular myocytes. Am J Physiol. 1998;275:H1808-17. Google Scholar

Ostrovsky L, King AJ, Bond S, Lorant DE, Zimmerman GA, Larsen R, Niu XF, Kubes P. A juxtacrine mechanism for neutrophil adhesion on platelets involves platelet-activating factor and a selectin-dependent activation process. Blood. 1998;91:3028-2036. Google Scholar

Zou A, Xu QP, Sanguinetti MC. A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation. J Physiol. 1998;509 ( Pt 1):129-37. Google Scholar

Litwin SE, Li J, Bridge JH. Na-Ca exchange and the trigger for sarcoplasmic reticulum Ca release: studies in adult rabbit ventricular myocytes. Biophys J. 1998;75:359-71. Google Scholar

Rudy Y, Taccardi B. Noninvasive imaging and catheter imaging of potentials, electrograms, and isochrones on the ventricular surfaces. J Electrocardiol. 1998;30 Suppl:19-23. Google Scholar

Ni Q, MacLeod RS, Lux RL, Taccardi B. A novel interpolation method for electric potential fields in the heart during excitation. PACE. 1998;26:597-607. Google Scholar

Prescott SM, McIntyre TM, Zimmerman GA. Platelet-activating factor (PAF): a phospholipid mediator of inflammation. J Biol Chem. 1998;In press. Google Scholar

MacLeod RS, Lux RL, Taccardi B. A possible mechanism for electrocardiographically silent changes in cardiac repolarization. J Electrocardiol. 1998;30:114-121. Google Scholar

Sobie EA, Tung L. Postshock potential gradients and dispersion of repolarization in cells stimulated with monophasic and biphasic waveforms. J Cardiovasc Electrophysiol. 1998;9:743-56. Google Scholar

Binhack S, Werner CD, Sachse FB, Dössel O. Preprocessing of the Visible Female data. Biomed Tech (Berl). 1998;43 Suppl:528-9. Google Scholar

Topham MK, Bunting M, Zimmerman GA, McIntyre TM, Blackshear PJ, Prescott SM. Protein kinase C regulates the nuclear localization of diacylglycerol kinase z. Nature. 1998;394:697-700. Google Scholar

Lux RL, Fuller MS, MacLeod RS, Ershler PR, Green LS, Taccardi B. QT interval dispersion. Dispersion of ventricular repolarization or dispersion of QT interval?. J Electrocardiol. 1998;30:176-180. Google Scholar

Punske BB, Cascio WE, Engle C, Nagle HT, Gettes LS, Johnson TA. Quantitative characterization of epicardial wave fronts during regional ischemia and elevated extracellular potassium ion concentration. Ann Biomed Eng. 1998;26:1010-1021. Google Scholar
Taccardi B, Punske BB, Lux RL, MacLeod R, Ershler PR, Dustman TJ, Ingebrigtsen N. Relationships between myocardial activity and potentials on the ventricular surfaces. J Electrocardiol. 1998;30:1-4. Google Scholar

Cordeiro JM, Spitzer KW, Giles WR. Repolarizing K+ currents in rabbit heart Purkinje cells. J Physiol. 1998;508:811-823. Google Scholar

Busch NH, Sachse FB, Werner CD, Dössel O. [Segmentation of clinical 4-dimensional magnetic resonance tomography images using active contour models and haptic interaction]. Biomed Tech (Berl). 1998;43 Suppl:526-7. Google Scholar

Sachse FB, Werner CD, Dössel O, Meyer-Waarden K. [Solution to the forward problem in electrocardiography from isotropic and anisotropic models of cardiac signal propagation]. Biomed Tech (Berl). 1998;43 Suppl:154-5. Google Scholar

P. Franzone C, Guerri L, Pennacchio M, Taccardi B. Spread of excitation in 3-D models of the anisotropic cardiac tissue. III. Effects of ventricular geometry and fiber structure on the potential distribution. Math Biosci. 1998;151:51-98. Google Scholar

Riemer TL, Sobie EA, Tung L. Stretch-induced changes in arrhythmogenesis and excitability in experimentally based heart cell models. Am J Physiol. 1998;275:H431-42. Google Scholar

Tristani-Firouzi M, Sanguinetti MC. Voltage-dependent inactivation of the human K+ channel KvLQT1 is eliminated by association with minimal K+ channel (minK) subunits. J Physiol. 1998;510 ( Pt 1):37-45. Google Scholar

 

1997

de Boer IH, Sachse FB, Dössel O. [3-D localization of electrodes in multichannel ECG recording using analysis of stereo color images]. Biomed Tech (Berl). 1997;42 Suppl:129-30. Google Scholar

Navarro-Polanco RA, Sanchez-Chapula JA. 4-aminopyridine activates potassium currents by activation of a muscarinic receptor in feline atrial myocytes. J Physiol. 1997;498 ( Pt 3):663-78. Google Scholar

Taccardi B. Anatomical and microstructural factors affecting the electrical activity of the heart. Experimental findings and mathematical simulations. Bull Mem Acad R Med Belg. 1997;152:287-93; discussion 294. Google Scholar

Taccardi B, Lux RL, Ershler PR, MacLeod R, Dustman TJ, Ingebrigtsen N. Anatomical architecture and electrical activity of the heart. Acta Cardiol. 1997;52:91-105. Google Scholar

Pollard AE, Spitzer KW, Burgess MJ. Contributions of the specialized conduction system to the activation sequence in the canine pulmonary conus. Am J Physiol. 1997;273 (Heart Circ Physiol 42):H446-H463. Google Scholar

Abildskov JA, Lux RL. Effects of heart rate on vulnerability to fibrillation in a computer model. J Electrocardiol. 1997;30:307-313. Google Scholar

Ito N, Bartunek J, Spitzer KW, Lorell BH. Effects of the nitric oxide donor sodium nitroprusside on intracellular pH and contraction in hypertrophied myocytes. Circulation. 1997;95. Google Scholar

Spitzer KW, Sato N, Tanaka H, Firek L, Zaniboni M, Giles WR. Electrotonic modulation of electrical activity in rabbit atrioventricular node myocytes. Am J Physiol. 1997;273 (Heart Circ Physiol 42):H767-H776. Google Scholar

Grissom CK, Zimmerman GA, Whatley RE. Endothelial selectins in acute mountain sickness and high-altitude pulmonary edema. Chest. 1997;112:1572-1578. Google Scholar

Litwin SE, Bridge JH. Enhanced Na(+)-Ca2+ exchange in the infarcted heart. Implications for excitation-contraction coupling. Circ Res. 1997;81:1083-93. Google Scholar

Sobie EA, Susil RC, Tung L. A generalized activating function for predicting virtual electrodes in cardiac tissue. Biophys J. 1997;73:1410-23. Google Scholar

Abildskov JA, Lux RL. The individual roles of premature excitation and nonuniform propagation in vulnerability to simulated fibrillation. Am J Physiol. 1997:in press. Google Scholar

Abildskov JA, Lux RL. Mechanisms in adrenergic dependent onset of torsade de pointes. PACE. 1997;20:88-94. Google Scholar

Abildskov JA, Lux RL. Mechanisms in adrenergic dependent onset of torsades de pointes. Pacing Clin Electrophysiol. 1997;20:88-94. Google Scholar

Werner C, Sachse FB, Dössel O. [Modeling of impulse transmission in the heart exemplified by the Visible Man dataset]. Biomed Tech (Berl). 1997;42 Suppl:195-6. Google Scholar

Sanguinetti MC, Zou A. Molecular physiology of cardiac delayed rectifier K+ channels. Heart Vessels. 1997;Suppl 12:170-2. Google Scholar

Splawski I, Tristani-Firouzi M, Lehmann MH, Sanguinetti MC, Keating MT. Mutations in the hminK gene cause long QT syndrome and suppress IKs function. Nat Genet. 1997;17:338-40. Google Scholar

Liu ZW, Jia P, Ershler PR, Taccardi B, Lux RL, Khoury DS, Rudy Y. Noncontact endocardial mapping: Reconstruction of electrograms and isochrones from intracavitary probe potentials. J Cardiovasc Electrophysiol. 1997;8:415-431. Google Scholar
Oster HS, Taccardi B, Lux RL, Ershler PR, Rudy Y. Noninvasive electrocardiographic imaging: reconstruction of epicardial potentials, electrograms, and isochrones and localization of single and multiple electrocardiac events. Circulation. 1997;96:1012-24. Google Scholar

Stafforini DM, McIntyre TM, Zimmerman GA, Prescott SM. Platelet-activating factor acetylhydrolases. J Biol Chem. 1997;272:17895-17898. Google Scholar

Sanguinetti MC, Spector PS. Potassium channelopathies. Neuropharmacology. 1997;36:755-62. Google Scholar

Yao A, Spitzer KW, Ito N, Zaniboni M, Lorell BH, Barry WH. The restriction of diffusion of cations at the external surface of cardiac myocytes varies between species. Cell Calcium. 1997;22(6):431-438. Google Scholar

Modur V, Li Y, Zimmerman GA, Prescott SM, McIntyre TM. Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha. J Clin Invest. 1997;100. Google Scholar

Yao A, Matsui H, Spitzer KW, Bridge JH, Barry WH. Sarcoplasmic reticulum and Na+/Ca2+ exchanger function during early and late relaxation in ventricular myocytes. Am J Physiol. 1997;273:H2765-73. Google Scholar

Zou A, Curran ME, Keating MT, Sanguinetti MC. Single HERG delayed rectifier K+ channels expressed in Xenopus oocytes. Am J Physiol. 1997;272:H1309-14. Google Scholar

Markewitz BA, Elstad MR. Succinylcholine-induced hyperkalemia following prolonged pharmacologic neuromuscular blockage. CHEST. 1997;111:248-250. Google Scholar

Green LS, Fuller MP, Lux RL. Three-dimensional distribution of ST-T wave alternans during acute ischemia. J Cardiovasc Electrophysiol. 1997;8:1413-1419. Google Scholar

Hren R, Horacek BM. Value of simulated body surface potential maps as templates in localizing sites of ectopic activation for radiofrequency ablation. Physiol Meas. 1997;18:373-400. Google Scholar

 

1996

Weyrich AS, Elstad MR, McEver RP, McIntyre TM, Moore KL, Morrissey JH, Prescott SM, Zimmerman GA. Activated platelets signal chemokine synthesis by human monocytes. J Clin Invest. 1996;97:1525-1534. Google Scholar

Wooten RN, Modur VR, McIntyre TM, Weiss JJ. Borrelia buregdorferi outer membrane protein A induces nuclear translocation of nuclear factor-kB and inflammatory activation in human endothelial cells. J Immunol. 1996;In press. Google Scholar

Spector PS, Curran ME, Keating MT, Sanguinetti MC. Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides. Circ Res. 1996;78:499-503. Google Scholar

Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL, Keating MT. Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature. 1996;384:80-3. Google Scholar

Taccardi B, Lux RL, MacLeod RS, Ershler PR, Dustman TJ, Scott M, Vyhmeister Y, Ingebrigtsen N. ECG waveforms and cardiac electric sources. J Electrocardiol. 1996;29 Suppl:98-100. Google Scholar

Levi AJ, Li J, Spitzer KW, Bridge JHB. Effect on the indo-1 transient of applying Ca2+ channel blocker for a single beat in voltage-clamped guinea-pig cardiac myocytes. J Physiol. 1996;494:653-673. Google Scholar

Levi AJ, Li J, Spitzer KW, Bridge JH. Effect on the indo-1 transient of applying Ca2+ channel blocker for a single beat in voltage-clamped guinea-pig cardiac myocytes. J Physiol. 1996;494 ( Pt 3):653-73. Google Scholar

Abildskov JA, Lux RL. Effects of premature responses on vulnerability to fibrillation in a computer model. J Electrocardiol. 1996;29:213-221. Google Scholar

Modur V, Zimmerman GA, Prescott SM, McIntyre TM. Endothelial cell inflammatory responses to TNF alpha: Ceramide-dependent and independent MAP kinase cascades. J Biol Chem. 1996;271:13094-13102. Google Scholar

MacLeod RS, Lux RL, Fuller MS, Taccardi B. Evaluation of novel measurement methods for detecting heterogeneous repolarization. J Electrocardiol. 1996;29:145-153. Google Scholar

Goldberg GS, Moreno AP, Bechberger JF, Hearn SS, Shivers RR, MacPhee DJ, Zhang YC, Naus CC. Evidence that disruption of connexon particle arrangements in gap junction plaques is associated with inhibition of gap junctional communication by a glycyrrhetinic acid derivative. Exp Cell Res. 1996;222:48-53. Google Scholar

Litwin S, Kohmoto O, Levi AJ, Spitzer KW, Bridge JH. Evidence that reverse Na-Ca exchange can trigger SR calcium release. Ann N Y Acad Sci. 1996;779:451-63. Google Scholar

Spector PS, Curran ME, Zou A, Keating MT, Sanguinetti MC. Fast inactivation causes rectification of the IKr channel. J Gen Physiol. 1996;107:611-9. Google Scholar

Compton SJ, Lux RL, Ramsey MR, Strelich KR, Sanguinetti MC, Green LS, Keating MT, Mason JW. Genetically defined therapy of inherited long-QT syndrome. Correction of abnormal repolarization by potassium. Circulation. 1996;94:1018-1022. Google Scholar

Lux RL, Ershler PR, Taccardi B. Measuring spatial waves of repolarization in canine ventricles using high-resolution epicardial mapping. J Electrocardiol. 1996;29 Suppl:130-4. Google Scholar
Lux RL, Ershler PR, Taccardi PR. Measuring spatial waves of repolarization in canine ventricles Using high resolution epicardial mapping. J Electrocardiol. 1996;29:130-134. Google Scholar

Fishler MG, Sobie EA, Thakor NV, Tung L. Mechanisms of cardiac cell excitation with premature monophasic and biphasic field stimuli: a model study. Biophys J. 1996;70:1347-62. Google Scholar

Fishler MG, Sobie EA, Tung L, Thakor NV. Modeling the interaction between propagating cardiac waves and monophasic and biphasic field stimuli: the importance of the induced spatial excitatory response. J Cardiovasc Electrophysiol. 1996;7:1183-96. Google Scholar

Bunting M, Tang W, Zimmerman GA, McIntyre TM, Prescott SM. Molecular cloning and characterization of a novel human diacylglycerol kinase d containing a MARCKS domain and ankyrin repeats. J Biol Chem. 1996;271:10230-10236. Google Scholar

Tang W, Bunting M, Zimmerman GA, McIntyre TM, Prescott SM. Molecular cloning of a novel human diacylglycerol kinase highly selective for arachidonate-containing substrates. J Biol Chem. 1996;271:10237-10241. Google Scholar

Keating MT, Sanguinetti MC. Molecular genetic insights into cardiovascular disease. Science. 1996;272:681-5. Google Scholar

Fuller MS, Dustman TJ, Sharp S, Green LS, Lux RL. Optimal lead selection for detection of ST segment shifts. Pace. 1996;19:920-928. Google Scholar

Sheets MF, Kyle JW, Krueger S, Hanck DA. Optimization of a mammalian expression system for the measurement of sodium channel gating currents. Am J Physiol. 1996;271:C1001-6. Google Scholar

Stafforini DM, Satoh K, Atkinson DL, Tjoelker LW, Eberhardt C, Yoshida H, Imaizumi T-S, Takamatsu S, Zimmerman GA, McIntyre TM, Gray PW, Prescott SM. PAF acetylhydrolase deficiency: a missense mutation near the active site of an anti-inflammatory enzyme. J Clin Invest. 1996;97:2784-2791. Google Scholar

Keating MT, Sanguinetti MC. Pathophysiology of ion channel mutations. Curr Opin Genet Dev. 1996;6:326-33. Google Scholar

Stafforini DM, Satoh K, Atkinson DL, Tjoelker LW, Eberhardt C, Yoshida H, T.-A. I, Takamatsu S, Zimmerman GA, McIntyre TM, Gray PW, Prescott SM. Platelet-activating factor acetylhydrolase deficiency: a missense mutation near the active site of an anti-inflammatory phospholipase. J Clin Invest. 1996;97:2784-2791. Google Scholar

Sanguinetti MC, Curran ME, Spector PS, Keating MT. Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. Proc Natl Acad Sci U S A. 1996;93:2208-12. Google Scholar

Corotto FS, Piper DR, Chen N, Michel WC. Voltage- and Ca(2+)-gated currents in zebrafish olfactory receptor neurons. J Exp Biol. 1996;199:1115-26. Google Scholar

 

1995

Lorant DE, McEver RP, McIntyre TM, Moore KL, Prescott SM, Zimmerman GA. Activation of polymorphonuclear leukocytes reduces their adhesion to P-selectin and causes redistribution of ligands for P-selectin on their surfaces. J Clin Invest. 1995;96:171-182. Google Scholar

Schackow TE, Sheets MF, Eick RETen, Decker RS. Alteration of sodium channel kinetics in adult cat cardiac ventricular myocytes during primary culture. Am J Physiol Heart Circ Physiol. 1995;268:C993-C1001. Google Scholar

Matsui H, Barry WH, Livsey C, Spitzer KW. Angiotensin II stimulates sodium-hydrogen exchange in adult rabbit ventricular myocytes. Cardiovasc Res. 1995;29:215-221. Google Scholar

Tjoelker LW, Wilder C, Eberhardt C, Stafforini DM, Dietsch G, Schimpf B, Hooper S, Trong HL, Cousens LS, Zimmerman GA, Yamada Y, McIntyre TM, Prescott SM, Gray PW. Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. Nature . 1995;374:549-552. Google Scholar

Fishler MG, Sobie EA, Tung L, Thakor NV. Cardiac responses to premature monophasic and biphasic field stimuli. Results from cell and tissue modeling studies. J Electrocardiol. 1995;28 Suppl:174-9. Google Scholar

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Green LS, Abildskov JA. Clinical applications of body surface potential mapping. Clin Cardiol. 1995;18:245-249. Google Scholar

Watson AD, Navab M, Hama SY, Sevanian A, Prescott SM, Stafforini DM, McIntyre TM, La Du BN, Fogelman AM, Berliner JA. Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized-low density lipoprotein. J Clin Invest. 1995;1995:774-782. Google Scholar

Burgess MJ, Pollard AE, Spitzer KW, Yang L. Effects of premature beats on repolarization of postextrasystolic beats. Circulation. 1995;92:1969-1980. Google Scholar

MacLeod RS, Lux RL. Errors in ECG parameter estimation from standard leadsets. J Electrocardiol. 1995;28:98-103. Google Scholar

Barry WH, Matsui H, Bridge JH, Spitzer KW. Excitation-contraction coupling in ventricular myocytes: effects of angiotensin II. Adv Exp Med Biol. 1995;382:31-9. Google Scholar

Kornreich F, Lux RL, MacLeod RS. Map representation and diagnostic performance of the standard 12-lead ECG. J Electrocardiol. 1995;28:121-123. Google Scholar
Abildskov JA, Lux RL. Mechanisms in the interruption of reentrant tachycardia by pacing. J Electrocardiol. 1995;28(2):107-114. Google Scholar

Sanguinetti MC, Jiang C, Curran ME, Keating MT. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell. 1995;81:299-307. Google Scholar

Peeters GA, Sanguinetti MC, Eki Y, Konarzewska H, Renlund DG, Karwande SV, Barry WH. Method for isolation of human ventricular myocytes from single endocardial and epicardial biopsies. Am J Physiol. 1995;268:H1757-64. Google Scholar

Hanck DA, Sheets MF. Modification of inactivation in cardiac sodium channels: ionic current studies with Anthopleurin-A toxin. J Gen Physiol. 1995;106:601-16. Google Scholar

Weyrich AS, McIntyre TM, McEver RP, Prescott SM, Zimmerman GA. Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-a secretion. J Clin Invest. 1995;95:2297-2303. Google Scholar

Kralios FA, Anderson FL, Hanson GR, Kralios AC. Myocardial electrophysiological effects of neuropeptide Y in dogs. Am J Physiol . 1995;268(Heart Circ Physiol 37):H2195-H2201. Google Scholar

Tjoelker LW, Eberhardt C, J. U, Trong HL, Zimmerman GA, McIntyre TM, Stafforini DM, Prescott SM, Gray PW. Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A 2 with a catalytic triad . J Biol Chem. 1995;270:25481-25487. Google Scholar

Moreno AP, Laing JG, Beyer EC, Spray DC. Properties of gap junction channels formed of connexin 45 endogenously expressed in human hepatoma (SKHep1) cells. Am J Physiol. 1995;268:C356-65. Google Scholar

Elstad MR, Cowley FS, , McIntyre TM, Prescott SM, Zimmerman GA. P-selectin regulates platelet-activating factor synthesis and phagocytosis by monocytes. J Immunol. 1995;155:2109-2122. Google Scholar

Khoury DS, Taccardi B, Lux RL, Ershler PR, Rudy Y. Reconstruction of endocardial potentials and activation sequences from intracavitary probe measurements. Localization of pacing sites and effects of myocardial structure. Circulation. 1995;91:845-63. Google Scholar

Konarzewska H, Peeters GA, Sanguinetti MC. Repolarizing K+ currents in nonfailing human hearts. Similarities between right septal subendocardial and left subepicardial ventricular myocytes. Circulation. 1995;92:1179-87. Google Scholar

Tjoelker LW, Eberhardt C, Unger J, Trong HL, Zimmerman GA, McZIntyre TM, Stafforini DM, Prescott SM, Gray PW. Structural characterization of plasma platelet-activating factor acetylhyydrolase. A secreted phospholipase A2 with a catalytic triad. J Biol Chem. 1995;270:25481-25487. Google Scholar

Sheets MF, Hanck DA. Voltage-dependent open-state inactivation of cardiac sodium channels: gating current studies with Anthopleurin-A toxin. J Gen Physiol. 1995;106:617-40. Google Scholar

 

1994

Abildskov JA, Lux RL. Additions to the wavelet hypothesis of cardiac fibrillation. J Cardiovasc Electrophysiol. 1994;5:553-559. Google Scholar

Abildskov JA. Additions to the wavelet hypothesis of cardiac fibrillation. J Cardiovasc Electrophysiol. 1994;5(7):553-559. Google Scholar

MacLeod RS, Brooks DH, On H, Krim H, Lux RL, Kornreich F. Analysis of PTCA-induced ischemia using an ECG inverse solution or the wavelet transform. J Electrocardiol. 1994;27 Suppl:93-100. Google Scholar

Lux RL, Green LS, MacLeod RS, Taccardi B. Assessment of spatial and temporal characteristics of ventricular repolarization. J Electrocardiol. 1994;27(Suppl):100-105. Google Scholar

Kornreich F, MacLeod RS, Dzavid V, Kornreich AM, Stoupel E, de Almeida J, Walker D, Montague TJ. Body surface potential mapping of QRST changes during and after percutaneous transluminal coronary angioplasty. J Electrocardiol. 1994;27. Google Scholar

Elstad MR, Parker CJ, Cowley FS, Wilcox LA, McIntyre TM, Prescott SM, Zimmerman GA. CD11b/CD18 integrin and a ß-glucan receptor act in concert to induce the synthesis of platelet-activation factor by monocytes. J Immunol. 1994;152:220-230. Google Scholar

Perez-Armendariz EM, Romano MC, Luna J, Miranda C, Bennett MV, Moreno AP. Characterization of gap junctions between pairs of Leydig cells from mouse testis. Am J Physiol. 1994;267:C570-80. Google Scholar

Abildskov JA, Lux RL. Cycle-length effects on the initiation of simulated torsade de pointes. J Electrocardiol. 1994;27(1):1-9. Google Scholar

Levi AJ, Spitzer KW, Kohmoto O, Bridge JHB. Depolarization-induced Ca entry via Na-Ca exchange triggers SR release and phasic contraction in guinea-pig cardiac myocytes. Am J Physiol: Heart Circ Physiol . 1994;266:H1422-H1433. Google Scholar

Levi AJ, Spitzer KW, Kohmoto O, Bridge JH. Depolarization-induced Ca entry via Na-Ca exchange triggers SR release in guinea pig cardiac myocytes. Am J Physiol. 1994;266:H1422-33. Google Scholar

Taccardi B, Macchi E, Lux RL, Ershler PR, Spaggiari S, Baruffi S, Vyhmeister Y. Effect of myocardial fiber direction on epicardial potentials. Circulation . 1994;90:3076-3090. Google Scholar

Zubair I, Pollard AE, Spitzer KW, Burgess MJ. Effects of activation sequence on the spatial distribution of repolarization properties. J Electrocardiol. 1994;27(2):115-127. Google Scholar
Ikenouchi H, Barry WH, Bridge JH, Weinberg EO, Apstein CS, Lorell BH. Effects of angiotensin II on intracellular Ca2+ and pH in isolated beating rabbit hearts and myocytes loaded with the indicator indo-1. J Physiol. 1994;480 ( Pt 2):203-15. Google Scholar

Abildskov JA, Lux RL. Entrainment of reentrant tachycardia in a computer model. J Electrocardiol. 1994;27:277-286. Google Scholar

Moreno AP, Rook MB, Fishman GI, Spray DC. Gap junction channels: distinct voltage-sensitive and -insensitive conductance states. Biophys J. 1994;67:113-9. Google Scholar

Moreno AP, Saez JC, Fishman GI, Spray DC. Human connexin43 gap junction channels. Regulation of unitary conductances by phosphorylation. Circ Res. 1994;74:1050-7. Google Scholar

Hanck DA, Makielski JC, Sheets MF. Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study. J Gen Physiol. 1994;103:19-43. Google Scholar

Taccardi BC, Lux RL, Ershler PR, MacLeod RS, Vyhmeister Y. Modern views on the spread of excitation in anisotropic heart muscle. Jpn Heart J. 1994;35:31-35. Google Scholar

Patel KD, Modur V, Zimmerman GA, Prescott SM, McIntyre TM. The necrotic venom of the brown recluse spider induces dysregulated endothelial cell-dependent neutrophil activation: Differential induction of GM-CSF, IL-8 and E-selectin expression. J Clin Invest. 1994;94:631-642. Google Scholar

Saez JC, Moreno AP, Spray DC. Norepinephrine induces Ca2+ release from intracellular stores in rat pinealocytes. J Pineal Res. 1994;16:57-64. Google Scholar

Kralios AC, Leonard MT, Anderson FL, Kralios FA. Prevention of extracellular K+ inhomogeneity across the ischemic border by coronary venous obstruction in the dog: Salutary antiarrhythmic effects of enhanced myocardial hydration. J Mol Cell Cardiol. 1994;26:1349-1356. Google Scholar

Whatley RE, K S, Zimmerman GA, McIntyre TM, Prescott SM. Proliferation-dependent changes in release of arachidonic acid from endothelial cells. J Clin Invest. 1994;94:1889-1900. Google Scholar

Kornreich F, MacLeod RS, Dzavik V, Selvester RH, Kornreich AM, Stoupel E, de Almeida J, Walker D, Montague TJ. QRST changes during and after percutaneous transluminal coronary angioplasty. J Electrocardiol. 1994;27 Suppl:113-7. Google Scholar

Kohomoto O, Levi AJ, Bridge JH. Relation between reverse sodium-calcium exchange and sarcoplasmic reticulum calcium release in guinea pig ventricular cells. Circ Res. 1994;74:550-4. Google Scholar

Kohmoto O, Levi AJ, Bridge JHB. Relation between reverse sodium-calcium exchange and sarcoplasmic reticulum calcium release in guinea pig ventricular cells. Circ Res. 1994;74:550-554. Google Scholar

Green LS, Lux RL, Ershler PR, Freedman RA, Marcus FI, Gear K. Resolution of pace mapping stimulus site separation using body surface potentials. Circulation. 1994;90(1):462-468. Google Scholar

Abildskov JA, Lux RL. Spiral waves in a computer model of cardiac excitation. PACE. 1994;17(5):944-952. Google Scholar

Bergdolt BA, Tanowitz HB, Wittner M, Morris SA, Bilezikian JP, Moreno AP, Spray DC. Trypanosoma cruzi: effects of infection on receptor-mediated chronotropy and Ca2+ mobilization in rat cardiac myocytes. Exp Parasitol. 1994;78:149-60. Google Scholar

 

1993

Spray DC, Moreno AP, Campos-de-Carvalho AC. Biophysical properties of the human cardiac gap junction channel. Braz J Med Biol Res. 1993;26:541-52. Google Scholar

Pollard AE, Burgess MJ, Spitzer KW. Computer simulation of three-dimensional propagation in ventricular myocardium. Effects of intramural fiber rotation and inhomogeneous conductivity on epicardial activation. Circ Res. 1993;72:744-756. Google Scholar

Chin TK, Spitzer KW, Philipson KD, Bridge JH. The effect of exchanger inhibitory peptide (XIP) on sodium-calcium exchange current in guinea pig ventricular cells. Circ Res. 1993;72:497-503. Google Scholar

Chin TK, Spitzer KW, Phillipson KD, Bridge JHB. The effect of exchanger inhibitory peptide (XIP) on sodium-calcium exchange current in guinea pig ventricular cells. Circ Res. 1993;72:497-503. Google Scholar

Lux RL. Electrocardiographic Mapping: Noninvasive electrophysiological cardiac imaging. Circulation. 1993;87:1040-1042. Google Scholar

Moreno AP, De Carvalho ACCampos, Christ G, Melman A, Spray DC. Gap junctions between human corpus cavernosum smooth muscle cells: gating properties and unitary conductance. Am J Physiol. 1993;264:C80-92. Google Scholar

De Carvalho ACCampos, Roy C, Moreno AP, Melman A, Hertzberg EL, Christ GJ, Spray DC. Gap junctions formed of connexin43 are found between smooth muscle cells of human corpus cavernosum. J Urol. 1993;149:1568-75. Google Scholar

Saez JC, Berthoud VM, Moreno AP, Spray DC. Gap junctions. Multiplicity of controls in differentiated and undifferentiated cells and possible functional implications. Adv Second Messenger Phosphoprotein Res. 1993;27:163-98. Google Scholar

Whatley RE, Stroud ED, Bunting M, Zimmerman GA, McIntyre TM, Prescott SM. Growth-dependent changes in arachidonic acid release from endothelial cells are mediated by protein kinase C and changes in diacylglycerol. J Biol Chem. 1993;268(20):16130-16138. Google Scholar
Lorant DE, Topham MK, Whatley RE, McEver RP, McIntyre TM, Prescott SM, Zimmerman GA. Inflammatory roles of P-Selectin. J Clin Invest. 1993;92:559-570. Google Scholar

Barry WH, Bridge JH. Intracellular calcium homeostasis in cardiac myocytes. Circulation. 1993;87:1806-1815. Google Scholar

Lux RL. Karhunen-Loeve representation of ECG data. J Electrocardiol. 1993;25(Suppl):195-198. Google Scholar

Sheets MF, Hanck DA. Modification of sodium channel inactivation by alpha-chymotrypsin in canine cardiac Purkinje cells. J Cardiovasc Electrophysiol. 1993;4:686-94. Google Scholar

Sheets MF, Hanck DA. Modification of sodium channel inactivation by -chymotrypsin in canine cardiac Purkinje cells. J Cardiovasc Electrophysiol. 1993;4:686-694. Google Scholar

Jones DA, Carlton DP, McIntyre TM, Zimmerman GA, Prescott SM. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J Biol Chem. 1993;268(12):9049-9054. Google Scholar

Venable ME, Zimmerman GA, McIntyre TM, Prescott SM. Platelet-activating factor: a phospholipid autacoid with diverse actions. J Lipid Res. 1993;34:691-702. Google Scholar

Kralios AC, Anderson FL, Kralios FA. Protective effect of coronary sinus obstruction from primary ischemia-induced ventricular fibrillation in the dog. Am Heart J. 1993;125:987-995. Google Scholar

Fujimoto T, Stroud E, Whatley RE, Prescott SM, Muszbek L, Laposata M, McEver R. P-selectin is acylated with palmitic acid and stearic acid at cysteine 766 through a thioester linkage. J Biol Chem. 1993;268 (15):11394-11400. Google Scholar

P. Franzone C, Guerri L, Taccardi B. Spread of excitation in a myocardial volume: Simulation studies in a model of anisotropic ventricular muscle activated by point stimulation. J Cardiovasc Electrophysiol. 1993;4:144-160. Google Scholar

Franzone PCColli, Guerri L, Taccardi B. Spread of excitation in a myocardial volume: simulation studies in a model of anisotropic ventricular muscle activated by point stimulation. J Cardiovasc Electrophysiol. 1993;4:144-60. Google Scholar

MacLeod RS, Lux RL, Taccardi B. Translation of body surface maps between different electrode configurations using a three-dimensional interpolation scheme. J Electrocardiol. 1993;28:179-182. Google Scholar

Kohmoto O, Ikenouchi H, Hirata Y, Momomur S, Serizawa T, Barry WH. Variable effects of endothelin-1 on [Ca2+]i transients, pHi, and contraction in ventricular myocytes. Am J Physiol. 1993;265:(Heart Circ Physiol34):H793-H800. Google Scholar

 

1992

Holland MR, Venable ME, Whatley RE, Zimmerman GA, McIntyre TM, Prescott SM. Activation of the acetyl-coenzyme A: Lysoplatelet-activating factor acetyltransferase regulates platelet-actor synthesis in human endothelial cells. J Biol Chem. 1992;267:22883-22890. Google Scholar

Johnson CR, MacLeod RS, Ershler PR. A computer model for the study of electrical current flow in the human thorax. Comput Biol Med. 1992;22(5):305-323. Google Scholar

Abildskov JA, Lux RL. Effects of nonuniform slowing of conduction on vulnerability to fibrillation in a computer model. J Cardiovasc Electrophysiol. 1992;3:48-55. Google Scholar

Abildskov JA, Lux RL. Effects of premature excitation and tachycardia on the spatial distribution of refractoriness and propagation of excitation in a computer model. J Electrocardiol. 1992;25(4 ):287-294. Google Scholar

Arisi G, Macchi E, Corradi C, Lux RL, Taccardi B. Epicardial excitation during ventricular pacing. Relative independence of breakthrough sites from excitation sequence in canine right ventricle. Circ Res. 1992;71:840-9. Google Scholar

Arisi G, Macchi E, C C, Lux RL, Taccardi BT. Epicardial excitation during ventricular pacing: Relative independence of breakthrough sites from excitation sequence in canine right ventricle. Circ Res. 1992;71:840-849. Google Scholar

Li Z, Smith CD, Smolley JR, Bridge JH, Frank JS, Philipson KD. Expression of the cardiac Na(+)-Ca2+ exchanger in insect cells using a baculovirus vector. J Biol Chem. 1992;267:7828-33. Google Scholar

Li Z, Smith CD, Smolley JR, Bridge JHB, Frank JS, Philipson KD. Expression of the Cardiac Na+-Ca2+ exchanger in insect cells using a baculovirus vector. J Biol Chem. 1992;267(11):7828-7833. Google Scholar

Hanck DA, Sheets MF. Extracellular divalent and trivalent cation effects on sodium current kinetics in single canine cardiac Purkinje cells. J Physiol. 1992;454:299-320. Google Scholar

Christ GJ, Moreno AP, Melman A, Spray DC. Gap junction-mediated intercellular diffusion of Ca2+ in cultured human corporal smooth muscle cells. Am J Physiol. 1992;263:C373-83. Google Scholar

Spray DC, Moreno AP, Eghbali B, Chanson M, Fishman GI. Gating of gap junction channels as revealed in cells stably transfected with wild type and mutant connexin cDNAs. Biophys J. 1992;62:48-50. Google Scholar

Lux RL. Karhunen-Loeve representation of ECG data. J Electrocardiol. 1992;25 Suppl:195-8. Google Scholar
Sheets MF, Hanck DA. Mechanisms of extracellular divalent and trivalent cation block of the sodium current in canine cardiac Purkinje cells. J Physiol. 1992;454:299-320. Google Scholar

Elstad MR. Midazolam-induced angioedema and bronchoconstriction. Crit Care Med. 1992;20:307-308. Google Scholar

Patel KD, Zimmerman GA, Prescott SM, McIntyre TM. Novel leukocyte agonists are released by endothelial cells exposed to peroxide. J Biol Chem . 1992;267(21):15168-15175. Google Scholar

Moreno AP, Fishman GI, Spray DC. Phosphorylation shifts unitary conductance and modifies voltage dependent kinetics of human connexin43 gap junction channels. Biophys J. 1992;62:51-3. Google Scholar

Spitzer KW, Bridge JH. Relationship between intracellular pH and tension development in resting ventricular muscle and myocytes. Am J Physiol. 1992;262:C316-27. Google Scholar

Hanck DA, Sheets MF. Time-dependent changes in kinetics of Na+ current in single canine cardiac Purkinje cells. Am J Physiol. 1992;262:H1197-207. Google Scholar

 

1991

Sheets MF, Hanck DA. Atrionatriuretic peptide and calcium-conducting sodium channels. Science. 1991;252:449-52. Google Scholar

Taccardi B. Body surface mapping and cardiac electric sources: A historical survey. J Electrocardiol. 1991;23(Suppl I):150-154. Google Scholar

Holland MR, McIntyre TM, Zimmerman GA, Prescott SM. Cardiovascular effects of platelet-activating factor. Trends Cardiovasc Med. 1991;1:117-121. Google Scholar

Spray DC, Moreno AP, Kessler JA, Dermietzel R. Characterization of gap junctions between cultured leptomeningeal cells. Brain Res. 1991;568:1-14. Google Scholar

Moreno AP, Eghbali B, Spray DC. Connexin32 gap junction channels in stably transfected cells. Equilibrium and kinetic properties. Biophys J. 1991;60:1267-77. Google Scholar

Moreno AP, Eghbali B, Spray DC. Connexin32 gap junction channels in stably transfected cells: unitary conductance. Biophys J. 1991;60:1254-66. Google Scholar

Freedman RA, Fuller MS, Greenberg GM, Ershler PR, Lux RL, McLaughlin TB, Menlove R, Green LS, Moddrelle D, Krall R. Detection and localization of prolonged epicardial electrograms with 64-lead body surface signal-averaged electrocardiography. Circulation . 1991;84:871-883. Google Scholar

Anderson KP, Walker R, Ershler PR, Fuller M, Dustman T, Menlove R, Karwandee SV, Lux RL. Determination of local myocardial electrical activation for activation sequence mapping. Circ Res. 1991;69:898-917. Google Scholar

Anderson KP, Walker R, Ershler PR, Fuller M, Dustman T, Menlove R, Karwandee SV, Lux RL. Determination of local myocardial electrical activation for activation sequence mapping. A statistical approach. Circ Res. 1991;69:898-917. Google Scholar

Spray DC, Chanson M, Moreno AP, Dermietzel R, Meda P. Distinctive gap junction channel types connect WB cells, a clonal cell line derived from rat liver. Am J Physiol. 1991;260:C513-27. Google Scholar

Abildskov JA, Lux RL. Distribution of QRST deflection areas in relation to repolarization and arrhythmias. J Electrocardiol. 1991;24:197-203. Google Scholar

Sheets MF, Hanck DA. Does atrial natriuretic peptide (ANP) produce a calcium-conducting sodium channel?. Science. 1991;252:448-450. Google Scholar

Hanashima K, Kubota I, Ozawa T, Shibata T, Yamaki M, Ikeda K, Yasui S. Effect of altered activation sequence on epicardial QRST area and refractory period in dogs. Circulation. 1991;84:1346-53. Google Scholar

Hirai M, Burgess MJ. Effects of sudden changes in cycle length and pacing site on canine cardiac surface QRST isoarea maps. J Electrocardiol. 1991;24:213-219. Google Scholar

Green LS, Taccardi B, Ershler PR, Lux RL. Epicardial potential mapping: Effects of conducting media on isopotential and isochrone distributions. Circulation . 1991;84:2513-2521. Google Scholar

Mori A, Hanashima N, Tsuboi Y, Hiraba H, Goto N, Sumino R. Fifth somatosensory cortex (SV) representation of the whole body surface in the medial bank of the anterior suprasylvian sulcus of the cat. Neurosci Res. 1991;11:198-208. Google Scholar

Fishman GI, Moreno AP, Spray DC, Leinwand LA. Functional analysis of human cardiac gap junction channel mutants. Proc Natl Acad Sci U S A. 1991;88:3525-3529. Google Scholar

Stremler KE, Stafforini DM, Prescott SM, McIntyre TM. Human plasma PAF acetylhydrolase: oxidatively-fragmented phospholipids as substrates. J Biol Chem. 1991;266:11095-11103. Google Scholar

Moreno AP, Arellano RO, Rivera A, Ramon F. Humoral factors reduce gap junction sensitivity to cytoplasmic pH. II. In vitro manipulations. Am J Physiol. 1991;260:C1039-45. Google Scholar
Moreno AP, Spray DC, Ramon F. Humoral factors reduce gap junction sensitivity to cytoplasmic pH. I. Organ ablation studies. Am J Physiol. 1991;260:C1028-38. Google Scholar

Christ GJ, Moreno AP, Parker ME, Gondre CM, Valcic M, Melman A, Spray DC. Intercellular communication through gap junctions: a potential role in pharmacomechanical coupling and syncytial tissue contraction in vascular smooth muscle isolated from the human corpus cavernosum. Life Sci. 1991;49:PL195-200. Google Scholar

Tarbet EB, Stafforini DM, Elstad MR, Zimmerman GA, McIntyre TM, Prescott SM. Liver cells secrete the plasma form of platelet-activating factor acetylhydrolase. J Biol Chem. 1991;266(25):16667-16673. Google Scholar

Abildskov JA, Lux RL. Local events in a computer model of cardiac excitation. J Cardiovasc Electrophysiol . 1991;2:45-52. Google Scholar

Abildskov JA, Lux RL. The mechanism of simulated torsade de pointes in a computer model of propagated excitation. J Cardiovasc Electrophysiol. 1991;2:224-237. Google Scholar

Spitzer KW, Steinhaus BM, Hirai M, Haws CW, Burgess MJ. Modulation of collision induced changes in canine heart repolarization by cycle length. J Electrocardiol. 1991;24:43-52. Google Scholar

Kozmann G, Green LS, Lux RL. Nonparametric identification of discriminative information in body surface maps. IEEE Trans Biomed Eng . 1991;38:1061-1068. Google Scholar

Smiley PL, Stremler KE, Prescott SM, Zimmerman GA, McIntyre TM. Oxidatively-fragmented phosphatidylcholines activate human neutrophils through the receptor for platelet-activating factor. J Biol Chem . 1991;266:11104-11110. Google Scholar

Shibata T, Kubota I, Ikeda K, Yamaki M, Hanashima K, Tsuiki K, Yasui S. Relation between the incidence of arrhythmias and ischemic ST-segment depression during dipyridamole electrocardiography test in patients with coronary artery disease. Jpn Heart J. 1991;32:751-8. Google Scholar

Kubota I, Shibata T, Hanashima K, Yamaki M, Ikeda K, Tsuiki K, Yasui S. Signal-averaged body surface mapping for the assessment of low-amplitude potentials. Detailed maps during early ventricular activation in normal subjects. J Electrocardiol. 1991;24:205-12. Google Scholar

Shibata T, Kubota I, Ikeda K, Yamaki M, Hanashima K, Tsuiki K, Yasui S. Signal-averaged body surface mapping for the assessment of low-amplitude potentials. Relation between ventricular depolarization and repolarization in normal subjects. Jpn Heart J. 1991;32:203-13. Google Scholar

Abildskov JA. The sympathetic imbalance hypothesis of QT interval prolongation. J Cardiovasc Electrophysiol. 1991;2:355-359. Google Scholar

Bridge JHB, Smolley J, Spitzer KW, Chin TK. Voltage dependence of sodium-calcium exchange and the control of calcium extrusion in the heart. Ann NY Acad Sci. 1991;639:34-47. Google Scholar

Bridge JH, Smolley J, Spitzer KW, Chin TK. Voltage dependence of sodium-calcium exchange and the control of calcium extrusion in the heart. Ann N Y Acad Sci. 1991;639:34-47. Google Scholar

 

1990

Yoshida H, Matsubara K, Haraoka S, Yamanari H, Ihara K, Hagiwara H, Kobiki N, Togawa J, Shiraki T, Lux RL, . [Changes in the ECG and myocardial blood flow of the right and left ventricular walls under acute pulmonary arterial stenosis]. Kokyu To Junkan. 1990;38:367-74. Google Scholar

Anderson KP, Lux RL, T. D. Comparison of QRS morphologies of spontaneous premature ventricular complexes and ventricular tachycardia induced with programmed stimulation. Am Heart J. 1990;119:1302-1311. Google Scholar

Anderson KP, Walker R, Lux RL, Ershler PR, Menlove R, Williams MR, Krall R, Moddrelle D. Conduction velocity depression and drug-induced ventricular tachyarrhythmias. Effects of lidocaine in the intact canine heart. Circulation. 1990;81:1024-38. Google Scholar

Anderson KP, Walker R, Lux RL, Ershler PR, R. M, Williams MR, Krall R, Moddrelle D. Conduction velocity depression and drug-induced ventricular tachyarrhythmias: Effects of lidocaine in the intact canine heart. CIRculation. 1990;81:1024-1038.