- Chaudhuri Lab
The Chaudhuri lab studies mitochondrial calcium signaling and intracellular ion channels. A main goal is to define how heart failure alters mitochondrial calcium signalling, since calcium is a potent stimulator of ATP synthesis. A second goal is to study intracellular ion channels, utilizing our extensive experience in subcellular electrophysiological analysis.
- Dosdall Lab
Dosdall Lab studies
- Franklin Lab
The Franklin lab studies how the packaging of DNA around nucleosomes influences specific patterns of gene expression and how this packaging is modulated during disease to alter transcriptional activity. Their research aims to understand the mechanistic basis for how remodeling of chromatin induces the re-expression of fetal genes in the heart during the development of hypertrophy and failure.
- Junco Warren Lab
Dr. Warren’s research focuses on understanding the mechanisms involved in metabolic remodeling and cardiac energy deficits in the diseased and stressed heart. Her research over the last few years has used a multi-platform metabolomics approach, which provides a systems view of metabolic profile of diseased hearts.
- MacLeod Lab
The MacLeod lab studies electrocardiographic mapping of the heart and body surface. Specific research areas includes cardiac electrophysiology in the study of acute ischemia and repolarization abnormalities; and computational electrophysiology in solving electrocardiographic forward and inverse problems.
- Mark Warren Lab
The Mark Warren lab focuses on understanding the mechanisms involved in the initiation and perpetuation of atrial and ventricular fibrillation. Our lab uses fluorescent probes in combination with optical mapping techniques to investigate the macroscopic organization of fibrillation using whole heart preparations.
- Moreno Lab
The Moreno lab studies the molecular and biophysical properties of gap junctions. Specific areas of focus include intercellular heterologous communication, mathematical modeling of perm-selectivity of gap junction channel pores, and design of 3D structures for electrical recording.
- Sachse Lab
The Sachse lab studies cardiac electro-mechanics. This includes examining the biophysical modeling of ion channels, cells, and tissue; and confocal imaging.
- Tristani-Firouzi Lab
The Tristani-Firouzi lab studies the structural basis of K+ channel function and the cellular mechanisms that underlie susceptibility to arrhythmia. Specifically, the lab is focused on understanding how voltage-gated K+ channels “sense” the surrounding membrane potential and the mechanism(s) through which voltage-sensing is coupled to channel opening and inactivation.
- Zaitsev Lab
The Zaitsev lab studies cardiac arrhythmias and the imaging of cardiac excitation. Specific research projects include electrophysiologic mechanisms of initiation and perpetuation of cardiac fibrillation. We also study applications of techniques for visualization and analysis of wave dynamics during complex cardiac rhythms.