For years, scientists have known that someone who is thin could still end up with diabetes. Yet an obese person may be surprisingly healthy. Now, new research led by scientists at University of Utah College of Health and published in Cell Metabolism points toward an answer to that riddle. An accumulation of a toxic class of fat metabolites, known as ceramides, may increase the risk for type 2 diabetes. ... Read More
Diabetes & Metabolism Research Center
The Diabetes and Metabolism Research Center (DMRC) at University of Utah Health aims to bring together clinicians, researchers, and educators to broadly support research relating to diabetes, metabolism, and overall metabolic health.
The DMRC research scope spans the continuum from basic research studies using model systems to clinical trials. Studies on diabetes include investigations on the pathophysiology of diabetes, control of diabetes complications, and diabetes management strategies.
Research on metabolism ranges from basic investigations on mitochondrial biology and metabolic control to metabolic contributions to heart disease and cancer.
Our goal is to create a platform for innovative basic, translational, clinical, and population health research that will yield new prevention methods and treatments that ultimately improve metabolic health and quality of life.
University of Utah researchers have found that the structure of an insulin molecule produced by predatory cone snails may be an improvement over current fast-acting therapeutic insulin. The finding suggests that the cone snail insulin, produced by the snails to stun their prey, could begin working in as few as five minutes, compared with 15 minutes for the fastest-acting insulin currently available. ... Read MoreBiochemistry
Research led by Amnon Schlegel, M.D., Ph.D., Assistant Professor of Internal Medicine at the University of Utah School of Medicine and an Investigator with the University of Utah Molecular Medicine Program, reveals that defects in how the liver metabolizes glucose, caused by changes in the abundance of the FOXN3 protein, can also trigger increased blood sugar levels, and may explain why some individuals with a variation in the FOXN3 gene show signs of being at risk for diabetes.... Read MoreInternal Medicine
The University of Utah’s Diabetes and Metabolism Center (DMC) has awarded grants to seven projects designed to advance research and practices to improve outcomes for those impacted by diabetes, metabolic abnormalities, and obesity. This year’s recipients come from nine departments at the University of Utah School of Medicine, College of Humanities, and College of Science, and draw from a wide variety of related disciplines.... Read More
University of Utah Biochemist Is 1 of 4 Researchers Globally to Receive JDRF Grants to Develop ‘Smart’ Glucose-Responsive Insulin
University of Utah biochemist Danny Chou, Ph.D., is one of four researchers worldwide to receive a grant from the Juvenile Diabetes Research Foundation (JDRF) and the pharmaceutical company Sanofi US Services Inc. to develop glucose-responsive insulin to help millions of people with Type 1 diabetes (T1D) maintain proper blood glucose levels. ... Read MoreBiochemistry
Scientists have created a novel, long-lasting "smart" insulin that self-activates when blood sugar soars. Tests on mouse models for type 1 diabetes show that one injection works for a minimum of 14 hours, during which it can repeatedly and automatically lower blood sugar levels after simulated meals, mimicking blood sugar recovery in healthy mice. The finding represents an important advance in insulin therapy for diabetics and will be published Feb. 9 in PNAS Early Edition.... Read MoreBiochemistry