Research from the laboratory of Dr. Simon Fisher

Crystal structure of Vms1 highlighting the autoinhibitory domain (cyan) that is removed during mitochondrial stress -Research from the laboratory of Dr. Jared Rutter

GFP positive adipose progenitor cells were injected into a mouse model subcutaneously -Research from the laboratory of Dr. Sihem Boudina

Diabetes & Metabolism Research Center

The Diabetes and Metabolism Research Center (DMRC) at University of Utah Health aims to bring together clinicians, researchers, and educators to broadly support research relating to diabetes, metabolism, and overall metabolic health.

The DMRC research scope spans the continuum from basic research studies using model systems to clinical trials. Studies on diabetes include investigations on the pathophysiology of diabetes, control of diabetes complications, and diabetes management strategies.

Research on metabolism ranges from basic investigations on mitochondrial biology and metabolic control to metabolic contributions to heart disease and cancer.

Our goal is to create a platform for innovative basic, translational, clinical, and population health research that will yield new prevention methods and treatments that ultimately improve metabolic health and quality of life.

Latest News

Why Are Some Obese People at Higher Risk for Diabetes Than Others?
Nov 03, 2016

Why Are Some Obese People at Higher Risk for Diabetes Than Others?

Diabetes, Select..., , diabetes

For years, scientists have known that someone who is thin could still end up with diabetes. Yet an obese person may be surprisingly healthy. Now, new research led by scientists at University of Utah College of Health and published in Cell Metabolism points toward an answer to that riddle. An accumulation of a toxic class of fat metabolites, known as ceramides, may increase the risk for type 2 diabetes. ... Read More

Snails’ Speedy Insulin
Sep 12, 2016

Snails’ Speedy Insulin


University of Utah researchers have found that the structure of an insulin molecule produced by predatory cone snails may be an improvement over current fast-acting therapeutic insulin. The finding suggests that the cone snail insulin, produced by the snails to stun their prey, could begin working in as few as five minutes, compared with 15 minutes for the fastest-acting insulin currently available. ... Read More

A New Piece of the Type 2 Diabetes Puzzle
Jun 09, 2016

A New Piece of the Type 2 Diabetes Puzzle

Diabetes, , diabetes

Research led by Amnon Schlegel, M.D., Ph.D., Assistant Professor of Internal Medicine at the University of Utah School of Medicine and an Investigator with the University of Utah Molecular Medicine Program, reveals that defects in how the liver metabolizes glucose, caused by changes in the abundance of the FOXN3 protein, can also trigger increased blood sugar levels, and may explain why some individuals with a variation in the FOXN3 gene show signs of being at risk for diabetes.... Read More

Internal Medicine
Catalyzing Advances in Diabetes, Metabolism, and Obesity Research
Mar 28, 2016

Catalyzing Advances in Diabetes, Metabolism, and Obesity Research

Diabetes, , diabetes, obesity

The University of Utah’s Diabetes and Metabolism Center (DMC) has awarded grants to seven projects designed to advance research and practices to improve outcomes for those impacted by diabetes, metabolic abnormalities, and obesity. This year’s recipients come from nine departments at the University of Utah School of Medicine, College of Humanities, and College of Science, and draw from a wide variety of related disciplines.... Read More

University of Utah Biochemist Is 1 of 4 Researchers Globally to Receive JDRF Grants to Develop ‘Smart’ Glucose-Responsive Insulin
Feb 25, 2016

University of Utah Biochemist Is 1 of 4 Researchers Globally to Receive JDRF Grants to Develop ‘Smart’ Glucose-Responsive Insulin

diabetes, type 1 diabetes

University of Utah biochemist Danny Chou, Ph.D., is one of four researchers worldwide to receive a grant from the Juvenile Diabetes Research Foundation (JDRF) and the pharmaceutical company Sanofi US Services Inc. to develop glucose-responsive insulin to help millions of people with Type 1 diabetes (T1D) maintain proper blood glucose levels. ... Read More

Feb 09, 2015

Novel "Smart" Insulin Automatically Adjusts Blood Sugar in Diabetic Mouse Model

diabetes, insulin

Scientists have created a novel, long-lasting "smart" insulin that self-activates when blood sugar soars. Tests on mouse models for type 1 diabetes show that one injection works for a minimum of 14 hours, during which it can repeatedly and automatically lower blood sugar levels after simulated meals, mimicking blood sugar recovery in healthy mice. The finding represents an important advance in insulin therapy for diabetics and will be published Feb. 9 in PNAS Early Edition.... Read More


Upcoming Events

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Simon Fisher, MD, PhD
Chief, Division of Endocrinology, Metabolism and Diabetes
Professor of Internal Medicine

Jared Rutter, PhD
Professor of Biochemistry
Investigator, Howard Hughes Medical Institute

Contact Us

Bridget Hughes, PhD
Associate Director, Research Program Development
Vice President of Health Sciences Research Unit

Phone: 801-585-9304

Endocrinology Grand Round Lectures

Endocrinology Faculty Recruitment

The Division of Endocrinology, Metabolism and Diabetes, and Department of Internal Medicine recruits outstanding applicants to academic faculty positions to expand our high-priority research programs in diabetes, obesity, and metabolism.

Smart Insulin