Beckerle Lab

Studying Molecular Relationships to Develop Treatment Strategies for Leukemia & Lymphomas

Understanding Hematopoiesis: Blood Cell Development

In spite of decades of research, there are few treatment advances for leukemia and lymphomas patients. These life-threatening diseases of the bone marrow are defined by the build up of leukemia cells and failure of normal blood cell development (hematopoiesis).

It is clear that improved outcomes for these patients will depend on new therapeutic agents and treatment strategies. Their development requires a deep understanding of the molecular determinants governing normal and malignant hematopoiesis. 

Studying Models of Notch Signaling Cascade

Our recent work focuses on the Notch signaling cascade and its relationships to nuclear factors that govern stem cell self-renewal and lineage allocation in hematopoiesis.

In our laboratory, we are using mouse, zebra fish and cell culture models to decipher the molecular relationships between Notch, its binding partners and its co-regulators in both normal and malignant hematopoiesis.

Additionally, by uncovering the modifications that govern these relationships, we are working to develop novel therapeutic strategies to treat leukemia and lymphomas in children and adults.