In its effort to develop and implement strategies to stop the spread of infectious diseases, including Ebola, in health care settings, the Centers for Disease Control and Prevention (CDC) has chosen the University of Utah and five other institutions nationwide to partner with the agency to spur innovations that help control the transmission of such organisms.... Read More
A new clinical trial to test how a high dose of stem cells delivered via a method called “retrograde coronary sinus infusion” affects end stage heart failure patients is showing promising results. The trial, conducted by an international team led by researchers at the University of Utah School of Medicine, Salt Lake City, UT appears in the current issue of STEM CELLS Translational Medicine. ... Read More
Researchers have found that multiple myeloma patients with a genetic variation in the gene FOPNL die on average 1-3 years sooner than patients without it. The finding was identified with a genetic mapping technique, genome wide association studies (GWAS), and verified in patient populations from North America and Europe. Published in Nature Communications, this was the first study to survey the entire human genome for genetic variation influencing survival, and is a first step toward applying precision medicine to multiple myeloma.... Read More
A study suggests that differences in the routines of individual providers drives variation in antibiotic prescribing more than differences in patient characteristics, standards of practice at different hospitals, or clinical settings (emergency department, primary care, urgent care). The report, led by the Veterans Affairs Salt Lake City Health Care System and the University of Utah and published in the Annals of Internal Medicine, is an important step toward understanding the problem of antibiotic overuse, a major public health concern given the rise in antibiotic-resistant “superbugs”.... Read More
Despite an increasing ease in acquiring genetic information, the American Society of Human Genetics (ASHG) points out that doing so has consequences, particularly when it comes to children. It is this population, they say, that is the most vulnerable.
With this precaution in mind, the ASHG Workgroup on Pediatric Genetic and Genomic Testing has issued guidelines for genetic testing in children and adolescents that are based on a thorough review of studies on ethical, legal, and social implications (ELSI). The recommendations were published in The American Journal of Human Genetics. ... Read More
A new study reveals the genetic causes of a curious, rare syndrome that manifests as hypertension (high blood pressure) accompanied by short fingers (brachydactyly type E). Six unrelated families with the syndrome come from across the globe – United States, Turkey, France, South America, and two from Canada – yet share mutations that cluster in a small region of phosphodiesterase 3A (PDE3A). Functional studies imply the mutations change resistance of blood vessels, an underappreciated mechanism for regulating blood pressure. The findings, published in Nature Genetics, suggest new directions for investigating causes of hypertension in the general population. ... Read More
A new study suggests that engaging in low intensity activities such as standing may not be enough to offset the health hazards of sitting for long periods of time. On the bright side, adding two minutes of walking each hour to your routine just might do the trick. These findings were published in the Clinical Journal of the American Society of Nephrology (CJASN).... Read More
Scientists at the University of Utah and the University of Georgia have uncovered a pharmacological target that could enable development of novel drugs against antibiotic-resistant pathogens, including Methicillin-resistant Staphylococcus aureus (MRSA) and other infectious Gram-positive organisms such as Listeria and Mycobacterium tuberculosis. The target was revealed upon discovery of a Gram-positive bacteria-specific pathway for making heme, an essential iron-carrying molecule. The findings were reported in the journal, Proceedings of the National Academy of Sciences (PNAS). ... Read More
Hosted by University of Utah School of Medicine and faculty from the Divisions of Cardiothoracic Surgery and Cardiology, cardiology professionals from around the world will gather to learn and exchange ideas with world-renowned health leaders. ... Read More
A discovery by researchers at Huntsman Cancer Institute shows that looking at whether a man’s uncles and great-grandparents, among other second- and third-degree relatives, had prostate cancer could be as important as looking at whether his father had prostate cancer. A more complete family history would give physicians a new tool to decide whether or not a PSA test was appropriate.... Read More
In an environment where others struggle to survive, Tibetans thrive in the thin air on the Tibetan Plateau, with an average elevation of 14,800 feet. A University of Utah led study is the first to identify a genetic variation that contributes to the adaptation, and to reveal how it works. The research appears online in the journal Nature Genetics on Aug. 17, 2014.
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