Foundations in Personalized Health Care 2012 course

Syllabus

Date

Topic

Instructor(s)

1/9

Overview

  1. Welcome and course overview
  2. History and evolution of "Personalized Health Care" (PHC)
  3. Utah's fit with PHC research and clinical care
  4. Technology primer


Joshua Schiffman, MD
Larry Meyer, MD, PhD

1/16

University Holiday - No Class

1/23

Ethical and Legal Issues; Informed Consent

  1. Clinical and research use and sharing of data
  2. Legal considerations of PHC

Jeffrey Botkin, MD
Teneille Brown, JD

1/30

Human Genetics in Medicine
  1. Human genetics in medicine
  2. Vignette: Miller Syndrome


Lynn Jorde, PhD
Debbie Jorde

2/6

Genome Analysis: A Reality Check

  1. GWAS, direct-to-consumer testing
  2. Personal genome sequencing and analysis
  3. Vignette: Concierge health program


Nicola Camp, PhD
Mark Yandell, PhD
Leslie Lenert, MD

2/13

Genetics of Common Multifactorial Diseases

  1. IBD/Crohn Disease
  2. Psoriasis
  3. Pediatric cardiology
  4. Genetic counseling over the last three decades: Has personalized medicine already arrived?



Steve Guthery, MD
Larry Meyer, MD, PhD
Peter Gruber, MD, PhD
John Carey, MD

2/20

University Holiday - No Class

2/27

Cancer Genomics and Pharmacogenomics

Joshua Schiffman, MD
David Bearss, PhD

3/5

Pharmacogenomics

  1. What we think we know
  2. Vignette: Psychiatric drug screening


Mark Munger, PhD
Mike Spigarelli, MD, PhD

3/12

Spring Break - No Class

3/19

Family Histories in PHC

  1. Family histories and inherited cancer syndrome screening and surveillance.
  2. Genetic Counselor's perspective
  3. Vignette: Family histories in maternal fetal medicine.



Randy Burt, MD

Wendy Kohlmann, MS, CGC
Michael Varner, MD

3/26

Utah: Using Data for Discovery

  1. UPDB
  2. FURTHeR
  3. Vignette: Using pedigrees and linked databases in research


Ken Smith, PhD
Joyce Mitchell, PhD
Lisa Cannon Albright, PhD

4/2

Utah: Applying Data to Development

  1. UHIN
  2. ARUP Laboratories
  3. VA and syndrome surveillance
  4. Intermountain Healthcare


Matt Hoffman, MS
Art Brothman, PhD
Adi Gundlapalli, MD, PhD
Carrie Byington, MD

4/9

PHC and the Individual Patient

  1. Patient centered medical home & clinical decision support
  2. Applications of pharmacology
  3. Companion diagnostics


Michael Magill, MD


Mike Spigarelli, MD, PhD
David Grainger, PhD

4/16

PHC and the Population

  1. Effect of PHC on public health
  2. Outcomes research and PHC
  3. Economics and cost effectiveness


Steve Alder, PhD
Diana Brixner, PhD
David Sundwall, PhD

4/23

Panel discussion:
What is the future of PHC?

Final exam due: Futures paper with a question for the panel

Michael Varner, MD
Diana Brixner, RPh, PhD
Larry Meyer, MD, PhD
Joshua Schiffman, MD
Sunil Sharma, MD